DIS3L2-UBE2E3 Fusion FISH Probe
The DIS3L2-UBE2E3 Fusion FISH Probe is used to confirm a fusion of the DIS3L2 and UBE2E3 genes. The fusion of the DIS3L2 and UBE2E3 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DIS3L2-UBE2E3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DIS3L2-UBE2E3-20-RERE | 20 (40 μL) | 200 μL |
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| DIS3L2-UBE2E3-20-REOR | 20 (40 μL) | 200 μL |
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| DIS3L2-UBE2E3-20-REGO | 20 (40 μL) | 200 μL |
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| DIS3L2-UBE2E3-20-REGR | 20 (40 μL) | 200 μL |
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| DIS3L2-UBE2E3-20-REAQ | 20 (40 μL) | 200 μL |
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| DIS3L2-UBE2E3-20-ORRE | 20 (40 μL) | 200 μL |
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| DIS3L2-UBE2E3-20-OROR | 20 (40 μL) | 200 μL |
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| DIS3L2-UBE2E3-20-ORGO | 20 (40 μL) | 200 μL |
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| DIS3L2-UBE2E3-20-ORAQ | 20 (40 μL) | 200 μL |
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| DIS3L2-UBE2E3-20-GORE | 20 (40 μL) | 200 μL |
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| DIS3L2-UBE2E3-20-GOOR | 20 (40 μL) | 200 μL |
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| DIS3L2-UBE2E3-20-GOGO | 20 (40 μL) | 200 μL |
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| DIS3L2-UBE2E3-20-GOGR | 20 (40 μL) | 200 μL |
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| DIS3L2-UBE2E3-20-GOAQ | 20 (40 μL) | 200 μL |
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| DIS3L2-UBE2E3-20-GRRE | 20 (40 μL) | 200 μL |
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| DIS3L2-UBE2E3-20-GROR | 20 (40 μL) | 200 μL |
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| DIS3L2-UBE2E3-20-GRGO | 20 (40 μL) | 200 μL |
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| DIS3L2-UBE2E3-20-GRGR | 20 (40 μL) | 200 μL |
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| DIS3L2-UBE2E3-20-GRAQ | 20 (40 μL) | 200 μL |
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| DIS3L2-UBE2E3-20-AQRE | 20 (40 μL) | 200 μL |
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| DIS3L2-UBE2E3-20-AQOR | 20 (40 μL) | 200 μL |
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| DIS3L2-UBE2E3-20-AQGO | 20 (40 μL) | 200 μL |
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| DIS3L2-UBE2E3-20-AQGR | 20 (40 μL) | 200 μL |
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| DIS3L2-UBE2E3-20-AQAQ | 20 (40 μL) | 200 μL |
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UBE2E3 Gene Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2013]
Gene Name: Ubiquitin Conjugating Enzyme E2 E3
Chromosome: CHR2: 181845111 -181928150
Locus: 2q31.3
DIS3L2 Gene Summary
The protein encoded by this gene is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Mar 2012]
Gene Name: DIS3 Like 3'-5' Exoribonuclease 2
Chromosome: CHR2: 232826292 -233201908
Locus: 2q37.1
Gene Diseases
The DIS3L2 UBE2E3 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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