DIP2B-RTTN Fusion FISH Probe
The DIP2B-RTTN Fusion FISH Probe is used to confirm a fusion of the DIP2B and RTTN genes. The fusion of the DIP2B and RTTN genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DIP2B-RTTN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DIP2B-RTTN-20-RERE | 20 (40 μL) | 200 μL |
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| DIP2B-RTTN-20-REOR | 20 (40 μL) | 200 μL |
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| DIP2B-RTTN-20-REGO | 20 (40 μL) | 200 μL |
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| DIP2B-RTTN-20-REGR | 20 (40 μL) | 200 μL |
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| DIP2B-RTTN-20-REAQ | 20 (40 μL) | 200 μL |
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| DIP2B-RTTN-20-ORRE | 20 (40 μL) | 200 μL |
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| DIP2B-RTTN-20-OROR | 20 (40 μL) | 200 μL |
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| DIP2B-RTTN-20-ORGO | 20 (40 μL) | 200 μL |
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| DIP2B-RTTN-20-ORAQ | 20 (40 μL) | 200 μL |
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| DIP2B-RTTN-20-GORE | 20 (40 μL) | 200 μL |
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| DIP2B-RTTN-20-GOOR | 20 (40 μL) | 200 μL |
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| DIP2B-RTTN-20-GOGO | 20 (40 μL) | 200 μL |
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| DIP2B-RTTN-20-GOGR | 20 (40 μL) | 200 μL |
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| DIP2B-RTTN-20-GOAQ | 20 (40 μL) | 200 μL |
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| DIP2B-RTTN-20-GRRE | 20 (40 μL) | 200 μL |
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| DIP2B-RTTN-20-GROR | 20 (40 μL) | 200 μL |
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| DIP2B-RTTN-20-GRGO | 20 (40 μL) | 200 μL |
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| DIP2B-RTTN-20-GRGR | 20 (40 μL) | 200 μL |
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| DIP2B-RTTN-20-GRAQ | 20 (40 μL) | 200 μL |
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| DIP2B-RTTN-20-AQRE | 20 (40 μL) | 200 μL |
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| DIP2B-RTTN-20-AQOR | 20 (40 μL) | 200 μL |
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| DIP2B-RTTN-20-AQGO | 20 (40 μL) | 200 μL |
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| DIP2B-RTTN-20-AQGR | 20 (40 μL) | 200 μL |
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| DIP2B-RTTN-20-AQAQ | 20 (40 μL) | 200 μL |
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RTTN Gene Summary
This gene encodes a large protein whose specific function is unknown. Absence of the orthologous protein in mouse results in embryonic lethality with deficient axial rotation, abnormal differentiation of the neural tube, and randomized looping of the heart tube during development. In human, mutations in this gene are associated with polymicrogyria with seizures. In human fibroblasts this protein localizes at the ciliary basal bodies. Given the intracellular localization of this protein and the phenotypic effects of mutations, this gene is suspected of playing a role in the maintenance of normal ciliary structure which in turn effects the developmental process of left-right organ specification, axial rotation, and perhaps notochord development. [provided by RefSeq, Jan 2013]
Gene Name: Rotatin
Chromosome: CHR18: 67671042 -67872962
Locus: 18q22.2
DIP2B Gene Summary
This gene encodes a member of the disco-interacting protein homolog 2 protein family. The encoded protein contains a binding site for the transcriptional regulator DNA methyltransferase 1 associated protein 1 as well as AMP-binding sites. The presence of these sites suggests that the encoded protein may participate in DNA methylation. This gene is located near a folate-sensitive fragile site, and CGG-repeat expansion in the promoter of this gene which affects transcription has been detected in individuals containing this fragile site on chromosome 12. [provided by RefSeq, Aug 2011]
Gene Name: Disco Interacting Protein 2 Homolog B
Chromosome: CHR12: 50898767 -51142450
Locus: 12q13.12
Gene Diseases
The DIP2B RTTN Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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