DIAPH2-F8 Fusion FISH Probe
The DIAPH2-F8 Fusion FISH Probe is used to confirm a fusion of the DIAPH2 and F8 genes. The fusion of the DIAPH2 and F8 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DIAPH2-F8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DIAPH2-F8-20-RERE | 20 (40 μL) | 200 μL |
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| DIAPH2-F8-20-REOR | 20 (40 μL) | 200 μL |
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| DIAPH2-F8-20-REGO | 20 (40 μL) | 200 μL |
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| DIAPH2-F8-20-REGR | 20 (40 μL) | 200 μL |
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| DIAPH2-F8-20-REAQ | 20 (40 μL) | 200 μL |
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| DIAPH2-F8-20-ORRE | 20 (40 μL) | 200 μL |
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| DIAPH2-F8-20-OROR | 20 (40 μL) | 200 μL |
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| DIAPH2-F8-20-ORGO | 20 (40 μL) | 200 μL |
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| DIAPH2-F8-20-ORAQ | 20 (40 μL) | 200 μL |
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| DIAPH2-F8-20-GORE | 20 (40 μL) | 200 μL |
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| DIAPH2-F8-20-GOOR | 20 (40 μL) | 200 μL |
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| DIAPH2-F8-20-GOGO | 20 (40 μL) | 200 μL |
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| DIAPH2-F8-20-GOGR | 20 (40 μL) | 200 μL |
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| DIAPH2-F8-20-GOAQ | 20 (40 μL) | 200 μL |
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| DIAPH2-F8-20-GRRE | 20 (40 μL) | 200 μL |
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| DIAPH2-F8-20-GROR | 20 (40 μL) | 200 μL |
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| DIAPH2-F8-20-GRGO | 20 (40 μL) | 200 μL |
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| DIAPH2-F8-20-GRGR | 20 (40 μL) | 200 μL |
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| DIAPH2-F8-20-GRAQ | 20 (40 μL) | 200 μL |
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| DIAPH2-F8-20-AQRE | 20 (40 μL) | 200 μL |
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| DIAPH2-F8-20-AQOR | 20 (40 μL) | 200 μL |
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| DIAPH2-F8-20-AQGO | 20 (40 μL) | 200 μL |
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| DIAPH2-F8-20-AQGR | 20 (40 μL) | 200 μL |
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| DIAPH2-F8-20-AQAQ | 20 (40 μL) | 200 μL |
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DIAPH2 Gene Summary
The product of this gene belongs to the diaphanous subfamily of the formin homology family of proteins. This gene may play a role in the development and normal function of the ovaries. Defects in this gene have been linked to premature ovarian failure 2. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Diaphanous Related Formin 2
Chromosome: CHRX: 95939661 -96855597
Locus: Xq21.33
F8 Gene Summary
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008]
Gene Name: Coagulation Factor VIII
Chromosome: CHRX: 154064063 -154250998
Locus: Xq28
Gene Diseases
The DIAPH2 F8 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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