DHX8-PPY Fusion FISH Probe
The DHX8-PPY Fusion FISH Probe is used to confirm a fusion of the DHX8 and PPY genes. The fusion of the DHX8 and PPY genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DHX8-PPY-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DHX8-PPY-20-RERE | 20 (40 μL) | 200 μL |
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| DHX8-PPY-20-REOR | 20 (40 μL) | 200 μL |
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| DHX8-PPY-20-REGO | 20 (40 μL) | 200 μL |
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| DHX8-PPY-20-REGR | 20 (40 μL) | 200 μL |
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| DHX8-PPY-20-REAQ | 20 (40 μL) | 200 μL |
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| DHX8-PPY-20-ORRE | 20 (40 μL) | 200 μL |
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| DHX8-PPY-20-OROR | 20 (40 μL) | 200 μL |
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| DHX8-PPY-20-ORGO | 20 (40 μL) | 200 μL |
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| DHX8-PPY-20-ORAQ | 20 (40 μL) | 200 μL |
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| DHX8-PPY-20-GORE | 20 (40 μL) | 200 μL |
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| DHX8-PPY-20-GOOR | 20 (40 μL) | 200 μL |
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| DHX8-PPY-20-GOGO | 20 (40 μL) | 200 μL |
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| DHX8-PPY-20-GOGR | 20 (40 μL) | 200 μL |
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| DHX8-PPY-20-GOAQ | 20 (40 μL) | 200 μL |
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| DHX8-PPY-20-GRRE | 20 (40 μL) | 200 μL |
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| DHX8-PPY-20-GROR | 20 (40 μL) | 200 μL |
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| DHX8-PPY-20-GRGO | 20 (40 μL) | 200 μL |
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| DHX8-PPY-20-GRGR | 20 (40 μL) | 200 μL |
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| DHX8-PPY-20-GRAQ | 20 (40 μL) | 200 μL |
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| DHX8-PPY-20-AQRE | 20 (40 μL) | 200 μL |
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| DHX8-PPY-20-AQOR | 20 (40 μL) | 200 μL |
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| DHX8-PPY-20-AQGO | 20 (40 μL) | 200 μL |
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| DHX8-PPY-20-AQGR | 20 (40 μL) | 200 μL |
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| DHX8-PPY-20-AQAQ | 20 (40 μL) | 200 μL |
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DHX8 Gene Summary
This gene is a member of the DEAH box polypeptide family. The encoded protein contains the DEAH (Asp-Glu-Ala-His) motif which is characteristic of all DEAH box proteins, and is thought to function as an ATP-dependent RNA helicase that regulates the release of spliced mRNAs from spliceosomes prior to their export from the nucleus. This protein may be required for the replication of human immunodeficiency virus type 1 (HIV-1). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Gene Name: DEAH-box Helicase 8
Chromosome: CHR17: 41561333 -41601680
Locus: 17q21.31
PPY Gene Summary
This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded 95 aa preproprotein is synthesized in the pancreatic islets of Langerhans and proteolytically processed to generate two peptide products. These products include the active pancreatic hormone of 36 aa and an icosapeptide of unknown function. This hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Gene Name: Pancreatic Polypeptide
Chromosome: CHR17: 42018171 -42019833
Locus: 17q21.31
Gene Diseases
The DHX8 PPY Fusion has been associated with the following diseases:
| Disease Name |
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| Colon Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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