DHX34-SAE1 Fusion FISH Probe
The DHX34-SAE1 Fusion FISH Probe is used to confirm a fusion of the DHX34 and SAE1 genes. The fusion of the DHX34 and SAE1 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DHX34-SAE1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DHX34-SAE1-20-RERE | 20 (40 μL) | 200 μL |
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| DHX34-SAE1-20-REOR | 20 (40 μL) | 200 μL |
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| DHX34-SAE1-20-REGO | 20 (40 μL) | 200 μL |
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| DHX34-SAE1-20-REGR | 20 (40 μL) | 200 μL |
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| DHX34-SAE1-20-REAQ | 20 (40 μL) | 200 μL |
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| DHX34-SAE1-20-ORRE | 20 (40 μL) | 200 μL |
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| DHX34-SAE1-20-OROR | 20 (40 μL) | 200 μL |
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| DHX34-SAE1-20-ORGO | 20 (40 μL) | 200 μL |
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| DHX34-SAE1-20-ORAQ | 20 (40 μL) | 200 μL |
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| DHX34-SAE1-20-GORE | 20 (40 μL) | 200 μL |
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| DHX34-SAE1-20-GOOR | 20 (40 μL) | 200 μL |
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| DHX34-SAE1-20-GOGO | 20 (40 μL) | 200 μL |
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| DHX34-SAE1-20-GOGR | 20 (40 μL) | 200 μL |
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| DHX34-SAE1-20-GOAQ | 20 (40 μL) | 200 μL |
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| DHX34-SAE1-20-GRRE | 20 (40 μL) | 200 μL |
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| DHX34-SAE1-20-GROR | 20 (40 μL) | 200 μL |
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| DHX34-SAE1-20-GRGO | 20 (40 μL) | 200 μL |
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| DHX34-SAE1-20-GRGR | 20 (40 μL) | 200 μL |
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| DHX34-SAE1-20-GRAQ | 20 (40 μL) | 200 μL |
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| DHX34-SAE1-20-AQRE | 20 (40 μL) | 200 μL |
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| DHX34-SAE1-20-AQOR | 20 (40 μL) | 200 μL |
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| DHX34-SAE1-20-AQGO | 20 (40 μL) | 200 μL |
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| DHX34-SAE1-20-AQGR | 20 (40 μL) | 200 μL |
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| DHX34-SAE1-20-AQAQ | 20 (40 μL) | 200 μL |
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DHX34 Gene Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. It is mapped to the glioma 19q tumor suppressor region and is a tumor suppressor candidate gene. [provided by RefSeq, Jul 2008]
Gene Name: DExH-box Helicase 34
Chromosome: CHR19: 47852537 -47885961
Locus: 19q13.32
SAE1 Gene Summary
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]
Gene Name: SUMO1 Activating Enzyme Subunit 1
Chromosome: CHR19: 47634079 -47713893
Locus: 19q13.32
Gene Diseases
The DHX34 SAE1 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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