DHX16-HLA-E Fusion FISH Probe
The DHX16-HLA-E Fusion FISH Probe is used to confirm a fusion of the DHX16 and HLA-E genes. The fusion of the DHX16 and HLA-E genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DHX16-HLA-E-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DHX16-HLA-E-20-RERE | 20 (40 μL) | 200 μL |
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| DHX16-HLA-E-20-REOR | 20 (40 μL) | 200 μL |
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| DHX16-HLA-E-20-REGO | 20 (40 μL) | 200 μL |
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| DHX16-HLA-E-20-REGR | 20 (40 μL) | 200 μL |
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| DHX16-HLA-E-20-REAQ | 20 (40 μL) | 200 μL |
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| DHX16-HLA-E-20-ORRE | 20 (40 μL) | 200 μL |
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| DHX16-HLA-E-20-OROR | 20 (40 μL) | 200 μL |
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| DHX16-HLA-E-20-ORGO | 20 (40 μL) | 200 μL |
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| DHX16-HLA-E-20-ORAQ | 20 (40 μL) | 200 μL |
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| DHX16-HLA-E-20-GORE | 20 (40 μL) | 200 μL |
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| DHX16-HLA-E-20-GOOR | 20 (40 μL) | 200 μL |
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| DHX16-HLA-E-20-GOGO | 20 (40 μL) | 200 μL |
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| DHX16-HLA-E-20-GOGR | 20 (40 μL) | 200 μL |
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| DHX16-HLA-E-20-GOAQ | 20 (40 μL) | 200 μL |
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| DHX16-HLA-E-20-GRRE | 20 (40 μL) | 200 μL |
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| DHX16-HLA-E-20-GROR | 20 (40 μL) | 200 μL |
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| DHX16-HLA-E-20-GRGO | 20 (40 μL) | 200 μL |
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| DHX16-HLA-E-20-GRGR | 20 (40 μL) | 200 μL |
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| DHX16-HLA-E-20-GRAQ | 20 (40 μL) | 200 μL |
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| DHX16-HLA-E-20-AQRE | 20 (40 μL) | 200 μL |
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| DHX16-HLA-E-20-AQOR | 20 (40 μL) | 200 μL |
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| DHX16-HLA-E-20-AQGO | 20 (40 μL) | 200 μL |
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| DHX16-HLA-E-20-AQGR | 20 (40 μL) | 200 μL |
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| DHX16-HLA-E-20-AQAQ | 20 (40 μL) | 200 μL |
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HLA-E Gene Summary
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008]
Gene Name: Major Histocompatibility Complex, Class I, E
Chromosome: CHR6_cox_hap2: 1969246 -1974046
Locus: 6p22.1
DHX16 Gene Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a functional homolog of fission yeast Prp8 protein involved in cell cycle progression. This gene is mapped to the MHC region on chromosome 6p21.3, a region where many malignant, genetic and autoimmune disease genes are linked. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Gene Name: DEAH-box Helicase 16
Chromosome: CHR6_ssto_hap7: 1953167 -1973134
Locus: 6p21.33
Gene Diseases
The DHX16 HLA-E Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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