DHCR24-SFTPC Fusion FISH Probe
The DHCR24-SFTPC Fusion FISH Probe is used to confirm a fusion of the DHCR24 and SFTPC genes. The fusion of the DHCR24 and SFTPC genes has been associated with Lung Adenocarcinoma, and Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DHCR24-SFTPC-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DHCR24-SFTPC-20-RERE | 20 (40 μL) | 200 μL |
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| DHCR24-SFTPC-20-REOR | 20 (40 μL) | 200 μL |
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| DHCR24-SFTPC-20-REGO | 20 (40 μL) | 200 μL |
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| DHCR24-SFTPC-20-REGR | 20 (40 μL) | 200 μL |
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| DHCR24-SFTPC-20-REAQ | 20 (40 μL) | 200 μL |
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| DHCR24-SFTPC-20-ORRE | 20 (40 μL) | 200 μL |
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| DHCR24-SFTPC-20-OROR | 20 (40 μL) | 200 μL |
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| DHCR24-SFTPC-20-ORGO | 20 (40 μL) | 200 μL |
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| DHCR24-SFTPC-20-ORAQ | 20 (40 μL) | 200 μL |
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| DHCR24-SFTPC-20-GORE | 20 (40 μL) | 200 μL |
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| DHCR24-SFTPC-20-GOOR | 20 (40 μL) | 200 μL |
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| DHCR24-SFTPC-20-GOGO | 20 (40 μL) | 200 μL |
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| DHCR24-SFTPC-20-GOGR | 20 (40 μL) | 200 μL |
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| DHCR24-SFTPC-20-GOAQ | 20 (40 μL) | 200 μL |
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| DHCR24-SFTPC-20-GRRE | 20 (40 μL) | 200 μL |
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| DHCR24-SFTPC-20-GROR | 20 (40 μL) | 200 μL |
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| DHCR24-SFTPC-20-GRGO | 20 (40 μL) | 200 μL |
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| DHCR24-SFTPC-20-GRGR | 20 (40 μL) | 200 μL |
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| DHCR24-SFTPC-20-GRAQ | 20 (40 μL) | 200 μL |
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| DHCR24-SFTPC-20-AQRE | 20 (40 μL) | 200 μL |
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| DHCR24-SFTPC-20-AQOR | 20 (40 μL) | 200 μL |
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| DHCR24-SFTPC-20-AQGO | 20 (40 μL) | 200 μL |
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| DHCR24-SFTPC-20-AQGR | 20 (40 μL) | 200 μL |
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| DHCR24-SFTPC-20-AQAQ | 20 (40 μL) | 200 μL |
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DHCR24 Gene Summary
This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008]
Gene Name: 24-dehydrocholesterol Reductase
Chromosome: CHR1: 55315299 -55352921
Locus: 1p32.3
SFTPC Gene Summary
This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.[provided by RefSeq, Feb 2010]
Gene Name: Surfactant Protein C
Chromosome: CHR8: 22019183 -22021991
Locus: 8p21.3
Gene Diseases
The DHCR24 SFTPC Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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