DHCR24-NDUFV1 Fusion FISH Probe
The DHCR24-NDUFV1 Fusion FISH Probe is used to confirm a fusion of the DHCR24 and NDUFV1 genes. The fusion of the DHCR24 and NDUFV1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DHCR24-NDUFV1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DHCR24-NDUFV1-20-RERE | 20 (40 μL) | 200 μL |
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| DHCR24-NDUFV1-20-REOR | 20 (40 μL) | 200 μL |
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| DHCR24-NDUFV1-20-REGO | 20 (40 μL) | 200 μL |
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| DHCR24-NDUFV1-20-REGR | 20 (40 μL) | 200 μL |
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| DHCR24-NDUFV1-20-REAQ | 20 (40 μL) | 200 μL |
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| DHCR24-NDUFV1-20-ORRE | 20 (40 μL) | 200 μL |
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| DHCR24-NDUFV1-20-OROR | 20 (40 μL) | 200 μL |
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| DHCR24-NDUFV1-20-ORGO | 20 (40 μL) | 200 μL |
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| DHCR24-NDUFV1-20-ORAQ | 20 (40 μL) | 200 μL |
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| DHCR24-NDUFV1-20-GORE | 20 (40 μL) | 200 μL |
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| DHCR24-NDUFV1-20-GOOR | 20 (40 μL) | 200 μL |
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| DHCR24-NDUFV1-20-GOGO | 20 (40 μL) | 200 μL |
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| DHCR24-NDUFV1-20-GOGR | 20 (40 μL) | 200 μL |
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| DHCR24-NDUFV1-20-GOAQ | 20 (40 μL) | 200 μL |
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| DHCR24-NDUFV1-20-GRRE | 20 (40 μL) | 200 μL |
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| DHCR24-NDUFV1-20-GROR | 20 (40 μL) | 200 μL |
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| DHCR24-NDUFV1-20-GRGO | 20 (40 μL) | 200 μL |
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| DHCR24-NDUFV1-20-GRGR | 20 (40 μL) | 200 μL |
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| DHCR24-NDUFV1-20-GRAQ | 20 (40 μL) | 200 μL |
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| DHCR24-NDUFV1-20-AQRE | 20 (40 μL) | 200 μL |
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| DHCR24-NDUFV1-20-AQOR | 20 (40 μL) | 200 μL |
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| DHCR24-NDUFV1-20-AQGO | 20 (40 μL) | 200 μL |
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| DHCR24-NDUFV1-20-AQGR | 20 (40 μL) | 200 μL |
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| DHCR24-NDUFV1-20-AQAQ | 20 (40 μL) | 200 μL |
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DHCR24 Gene Summary
This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008]
Gene Name: 24-dehydrocholesterol Reductase
Chromosome: CHR1: 55315299 -55352921
Locus: 1p32.3
NDUFV1 Gene Summary
The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10,000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinson's disease and Leigh syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
Gene Name: NADH:ubiquinone Oxidoreductase Core Subunit V1
Chromosome: CHR11: 67374322 -67380012
Locus: 11q13.2
Gene Diseases
The DHCR24 NDUFV1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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