DHCR24-EPHX1 Fusion FISH Probe
The DHCR24-EPHX1 Fusion FISH Probe is used to confirm a fusion of the DHCR24 and EPHX1 genes. The fusion of the DHCR24 and EPHX1 genes has been associated with Liver Hepatocellular Carcinoma, Liver Hepatocellular Carcinoma, Adrenocortical Carcinoma, Adrenocortical Carcinoma, and Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DHCR24-EPHX1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DHCR24-EPHX1-20-RERE | 20 (40 μL) | 200 μL |
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| DHCR24-EPHX1-20-REOR | 20 (40 μL) | 200 μL |
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| DHCR24-EPHX1-20-REGO | 20 (40 μL) | 200 μL |
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| DHCR24-EPHX1-20-REGR | 20 (40 μL) | 200 μL |
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| DHCR24-EPHX1-20-REAQ | 20 (40 μL) | 200 μL |
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| DHCR24-EPHX1-20-ORRE | 20 (40 μL) | 200 μL |
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| DHCR24-EPHX1-20-OROR | 20 (40 μL) | 200 μL |
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| DHCR24-EPHX1-20-ORGO | 20 (40 μL) | 200 μL |
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| DHCR24-EPHX1-20-ORAQ | 20 (40 μL) | 200 μL |
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| DHCR24-EPHX1-20-GORE | 20 (40 μL) | 200 μL |
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| DHCR24-EPHX1-20-GOOR | 20 (40 μL) | 200 μL |
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| DHCR24-EPHX1-20-GOGO | 20 (40 μL) | 200 μL |
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| DHCR24-EPHX1-20-GOGR | 20 (40 μL) | 200 μL |
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| DHCR24-EPHX1-20-GOAQ | 20 (40 μL) | 200 μL |
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| DHCR24-EPHX1-20-GRRE | 20 (40 μL) | 200 μL |
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| DHCR24-EPHX1-20-GROR | 20 (40 μL) | 200 μL |
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| DHCR24-EPHX1-20-GRGO | 20 (40 μL) | 200 μL |
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| DHCR24-EPHX1-20-GRGR | 20 (40 μL) | 200 μL |
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| DHCR24-EPHX1-20-GRAQ | 20 (40 μL) | 200 μL |
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| DHCR24-EPHX1-20-AQRE | 20 (40 μL) | 200 μL |
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| DHCR24-EPHX1-20-AQOR | 20 (40 μL) | 200 μL |
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| DHCR24-EPHX1-20-AQGO | 20 (40 μL) | 200 μL |
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| DHCR24-EPHX1-20-AQGR | 20 (40 μL) | 200 μL |
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| DHCR24-EPHX1-20-AQAQ | 20 (40 μL) | 200 μL |
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DHCR24 Gene Summary
This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008]
Gene Name: 24-dehydrocholesterol Reductase
Chromosome: CHR1: 55315299 -55352921
Locus: 1p32.3
EPHX1 Gene Summary
Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2008]
Gene Name: Epoxide Hydrolase 1
Chromosome: CHR1: 225997796 -226033262
Locus: 1q42.12
Gene Diseases
The DHCR24 EPHX1 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
| Liver Hepatocellular Carcinoma |
| Adrenocortical Carcinoma |
| Adrenocortical Carcinoma |
| Adrenocortical Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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