DHCR24-CBS Fusion FISH Probe
The DHCR24-CBS Fusion FISH Probe is used to confirm a fusion of the DHCR24 and CBS genes. The fusion of the DHCR24 and CBS genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DHCR24-CBS-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DHCR24-CBS-20-RERE | 20 (40 μL) | 200 μL |
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| DHCR24-CBS-20-REOR | 20 (40 μL) | 200 μL |
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| DHCR24-CBS-20-REGO | 20 (40 μL) | 200 μL |
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| DHCR24-CBS-20-REGR | 20 (40 μL) | 200 μL |
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| DHCR24-CBS-20-REAQ | 20 (40 μL) | 200 μL |
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| DHCR24-CBS-20-ORRE | 20 (40 μL) | 200 μL |
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| DHCR24-CBS-20-OROR | 20 (40 μL) | 200 μL |
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| DHCR24-CBS-20-ORGO | 20 (40 μL) | 200 μL |
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| DHCR24-CBS-20-ORAQ | 20 (40 μL) | 200 μL |
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| DHCR24-CBS-20-GORE | 20 (40 μL) | 200 μL |
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| DHCR24-CBS-20-GOOR | 20 (40 μL) | 200 μL |
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| DHCR24-CBS-20-GOGO | 20 (40 μL) | 200 μL |
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| DHCR24-CBS-20-GOGR | 20 (40 μL) | 200 μL |
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| DHCR24-CBS-20-GOAQ | 20 (40 μL) | 200 μL |
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| DHCR24-CBS-20-GRRE | 20 (40 μL) | 200 μL |
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| DHCR24-CBS-20-GROR | 20 (40 μL) | 200 μL |
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| DHCR24-CBS-20-GRGO | 20 (40 μL) | 200 μL |
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| DHCR24-CBS-20-GRGR | 20 (40 μL) | 200 μL |
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| DHCR24-CBS-20-GRAQ | 20 (40 μL) | 200 μL |
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| DHCR24-CBS-20-AQRE | 20 (40 μL) | 200 μL |
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| DHCR24-CBS-20-AQOR | 20 (40 μL) | 200 μL |
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| DHCR24-CBS-20-AQGO | 20 (40 μL) | 200 μL |
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| DHCR24-CBS-20-AQGR | 20 (40 μL) | 200 μL |
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| DHCR24-CBS-20-AQAQ | 20 (40 μL) | 200 μL |
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CBS Gene Summary
The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2016]
Gene Name: Cystathionine-beta-synthase
Chromosome: CHR21: 44473300 -44496472
Locus: 21q22.3
DHCR24 Gene Summary
This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008]
Gene Name: 24-dehydrocholesterol Reductase
Chromosome: CHR1: 55315299 -55352921
Locus: 1p32.3
Gene Diseases
The DHCR24 CBS Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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