DGUOK-ACTG2 Fusion FISH Probe
The DGUOK-ACTG2 Fusion FISH Probe is used to confirm a fusion of the DGUOK and ACTG2 genes. The fusion of the DGUOK and ACTG2 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DGUOK-ACTG2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DGUOK-ACTG2-20-RERE | 20 (40 μL) | 200 μL |
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| DGUOK-ACTG2-20-REOR | 20 (40 μL) | 200 μL |
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| DGUOK-ACTG2-20-REGO | 20 (40 μL) | 200 μL |
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| DGUOK-ACTG2-20-REGR | 20 (40 μL) | 200 μL |
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| DGUOK-ACTG2-20-REAQ | 20 (40 μL) | 200 μL |
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| DGUOK-ACTG2-20-ORRE | 20 (40 μL) | 200 μL |
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| DGUOK-ACTG2-20-OROR | 20 (40 μL) | 200 μL |
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| DGUOK-ACTG2-20-ORGO | 20 (40 μL) | 200 μL |
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| DGUOK-ACTG2-20-ORAQ | 20 (40 μL) | 200 μL |
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| DGUOK-ACTG2-20-GORE | 20 (40 μL) | 200 μL |
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| DGUOK-ACTG2-20-GOOR | 20 (40 μL) | 200 μL |
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| DGUOK-ACTG2-20-GOGO | 20 (40 μL) | 200 μL |
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| DGUOK-ACTG2-20-GOGR | 20 (40 μL) | 200 μL |
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| DGUOK-ACTG2-20-GOAQ | 20 (40 μL) | 200 μL |
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| DGUOK-ACTG2-20-GRRE | 20 (40 μL) | 200 μL |
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| DGUOK-ACTG2-20-GROR | 20 (40 μL) | 200 μL |
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| DGUOK-ACTG2-20-GRGO | 20 (40 μL) | 200 μL |
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| DGUOK-ACTG2-20-GRGR | 20 (40 μL) | 200 μL |
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| DGUOK-ACTG2-20-GRAQ | 20 (40 μL) | 200 μL |
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| DGUOK-ACTG2-20-AQRE | 20 (40 μL) | 200 μL |
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| DGUOK-ACTG2-20-AQOR | 20 (40 μL) | 200 μL |
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| DGUOK-ACTG2-20-AQGO | 20 (40 μL) | 200 μL |
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| DGUOK-ACTG2-20-AQGR | 20 (40 μL) | 200 μL |
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| DGUOK-ACTG2-20-AQAQ | 20 (40 μL) | 200 μL |
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ACTG2 Gene Summary
Actins are highly conserved proteins that are involved in various types of cell motility and in the maintenance of the cytoskeleton. Three types of actins, alpha, beta and gamma, have been identified in vertebrates. Alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. This gene encodes actin gamma 2; a smooth muscle actin found in enteric tissues. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Based on similarity to peptide cleavage of related actins, the mature protein of this gene is formed by removal of two N-terminal peptides.[provided by RefSeq, Dec 2010]
Gene Name: Actin, Gamma 2, Smooth Muscle, Enteric
Chromosome: CHR2: 74120092 -74146780
Locus: 2p13.1
DGUOK Gene Summary
In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Deoxyguanosine Kinase
Chromosome: CHR2: 74153952 -74186088
Locus: 2p13.1
Gene Diseases
The DGUOK ACTG2 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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