DGKD-SP140 Fusion FISH Probe
The DGKD-SP140 Fusion FISH Probe is used to confirm a fusion of the DGKD and SP140 genes. The fusion of the DGKD and SP140 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DGKD-SP140-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DGKD-SP140-20-RERE | 20 (40 μL) | 200 μL |
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| DGKD-SP140-20-REOR | 20 (40 μL) | 200 μL |
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| DGKD-SP140-20-REGO | 20 (40 μL) | 200 μL |
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| DGKD-SP140-20-REGR | 20 (40 μL) | 200 μL |
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| DGKD-SP140-20-REAQ | 20 (40 μL) | 200 μL |
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| DGKD-SP140-20-ORRE | 20 (40 μL) | 200 μL |
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| DGKD-SP140-20-OROR | 20 (40 μL) | 200 μL |
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| DGKD-SP140-20-ORGO | 20 (40 μL) | 200 μL |
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| DGKD-SP140-20-ORAQ | 20 (40 μL) | 200 μL |
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| DGKD-SP140-20-GORE | 20 (40 μL) | 200 μL |
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| DGKD-SP140-20-GOOR | 20 (40 μL) | 200 μL |
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| DGKD-SP140-20-GOGO | 20 (40 μL) | 200 μL |
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| DGKD-SP140-20-GOGR | 20 (40 μL) | 200 μL |
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| DGKD-SP140-20-GOAQ | 20 (40 μL) | 200 μL |
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| DGKD-SP140-20-GRRE | 20 (40 μL) | 200 μL |
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| DGKD-SP140-20-GROR | 20 (40 μL) | 200 μL |
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| DGKD-SP140-20-GRGO | 20 (40 μL) | 200 μL |
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| DGKD-SP140-20-GRGR | 20 (40 μL) | 200 μL |
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| DGKD-SP140-20-GRAQ | 20 (40 μL) | 200 μL |
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| DGKD-SP140-20-AQRE | 20 (40 μL) | 200 μL |
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| DGKD-SP140-20-AQOR | 20 (40 μL) | 200 μL |
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| DGKD-SP140-20-AQGO | 20 (40 μL) | 200 μL |
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| DGKD-SP140-20-AQGR | 20 (40 μL) | 200 μL |
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| DGKD-SP140-20-AQAQ | 20 (40 μL) | 200 μL |
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DGKD Gene Summary
This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Diacylglycerol Kinase Delta
Chromosome: CHR2: 234263152 -234380743
Locus: 2q37.1
SP140 Gene Summary
This gene encodes a member of the SP100 family of proteins, which are share common domains including an N-terminal homogeneously staining region domain followed by a SP100/autoimmune regulator/NucP41/P75/deformed epidermal autoregulatory factor domain, a plant homeobox zinc finger, and a bromodomain. The encoded protein is interferon-inducible and is expressed at high levels in the nuclei of leukocytes. Variants of this gene have been associated with multiple sclerosis, Crohn's disease, and chronic lymphocytic leukemia. Alternative splicing results in multiple variants. [provided by RefSeq, Aug 2016]
Gene Name: SP140 Nuclear Body Protein
Chromosome: CHR2: 231090444 -231177930
Locus: 2q37.1
Gene Diseases
The DGKD SP140 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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