DGKD-INPP5D Fusion FISH Probe
The DGKD-INPP5D Fusion FISH Probe is used to confirm a fusion of the DGKD and INPP5D genes. The fusion of the DGKD and INPP5D genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DGKD-INPP5D-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DGKD-INPP5D-20-RERE | 20 (40 μL) | 200 μL |
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| DGKD-INPP5D-20-REOR | 20 (40 μL) | 200 μL |
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| DGKD-INPP5D-20-REGO | 20 (40 μL) | 200 μL |
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| DGKD-INPP5D-20-REGR | 20 (40 μL) | 200 μL |
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| DGKD-INPP5D-20-REAQ | 20 (40 μL) | 200 μL |
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| DGKD-INPP5D-20-ORRE | 20 (40 μL) | 200 μL |
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| DGKD-INPP5D-20-OROR | 20 (40 μL) | 200 μL |
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| DGKD-INPP5D-20-ORGO | 20 (40 μL) | 200 μL |
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| DGKD-INPP5D-20-ORAQ | 20 (40 μL) | 200 μL |
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| DGKD-INPP5D-20-GORE | 20 (40 μL) | 200 μL |
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| DGKD-INPP5D-20-GOOR | 20 (40 μL) | 200 μL |
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| DGKD-INPP5D-20-GOGO | 20 (40 μL) | 200 μL |
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| DGKD-INPP5D-20-GOGR | 20 (40 μL) | 200 μL |
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| DGKD-INPP5D-20-GOAQ | 20 (40 μL) | 200 μL |
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| DGKD-INPP5D-20-GRRE | 20 (40 μL) | 200 μL |
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| DGKD-INPP5D-20-GROR | 20 (40 μL) | 200 μL |
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| DGKD-INPP5D-20-GRGO | 20 (40 μL) | 200 μL |
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| DGKD-INPP5D-20-GRGR | 20 (40 μL) | 200 μL |
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| DGKD-INPP5D-20-GRAQ | 20 (40 μL) | 200 μL |
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| DGKD-INPP5D-20-AQRE | 20 (40 μL) | 200 μL |
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| DGKD-INPP5D-20-AQOR | 20 (40 μL) | 200 μL |
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| DGKD-INPP5D-20-AQGO | 20 (40 μL) | 200 μL |
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| DGKD-INPP5D-20-AQGR | 20 (40 μL) | 200 μL |
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| DGKD-INPP5D-20-AQAQ | 20 (40 μL) | 200 μL |
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INPP5D Gene Summary
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Gene Name: Inositol Polyphosphate-5-phosphatase D
Chromosome: CHR2: 233925035 -234116549
Locus: 2q37.1
DGKD Gene Summary
This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Diacylglycerol Kinase Delta
Chromosome: CHR2: 234263152 -234380743
Locus: 2q37.1
Gene Diseases
The DGKD INPP5D Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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