DGCR8-CRKL Fusion FISH Probe
The DGCR8-CRKL Fusion FISH Probe is used to confirm a fusion of the DGCR8 and CRKL genes. The fusion of the DGCR8 and CRKL genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DGCR8-CRKL-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DGCR8-CRKL-20-RERE | 20 (40 μL) | 200 μL |
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| DGCR8-CRKL-20-REOR | 20 (40 μL) | 200 μL |
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| DGCR8-CRKL-20-REGO | 20 (40 μL) | 200 μL |
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| DGCR8-CRKL-20-REGR | 20 (40 μL) | 200 μL |
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| DGCR8-CRKL-20-REAQ | 20 (40 μL) | 200 μL |
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| DGCR8-CRKL-20-ORRE | 20 (40 μL) | 200 μL |
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| DGCR8-CRKL-20-OROR | 20 (40 μL) | 200 μL |
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| DGCR8-CRKL-20-ORGO | 20 (40 μL) | 200 μL |
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| DGCR8-CRKL-20-ORAQ | 20 (40 μL) | 200 μL |
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| DGCR8-CRKL-20-GORE | 20 (40 μL) | 200 μL |
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| DGCR8-CRKL-20-GOOR | 20 (40 μL) | 200 μL |
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| DGCR8-CRKL-20-GOGO | 20 (40 μL) | 200 μL |
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| DGCR8-CRKL-20-GOGR | 20 (40 μL) | 200 μL |
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| DGCR8-CRKL-20-GOAQ | 20 (40 μL) | 200 μL |
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| DGCR8-CRKL-20-GRRE | 20 (40 μL) | 200 μL |
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| DGCR8-CRKL-20-GROR | 20 (40 μL) | 200 μL |
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| DGCR8-CRKL-20-GRGO | 20 (40 μL) | 200 μL |
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| DGCR8-CRKL-20-GRGR | 20 (40 μL) | 200 μL |
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| DGCR8-CRKL-20-GRAQ | 20 (40 μL) | 200 μL |
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| DGCR8-CRKL-20-AQRE | 20 (40 μL) | 200 μL |
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| DGCR8-CRKL-20-AQOR | 20 (40 μL) | 200 μL |
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| DGCR8-CRKL-20-AQGO | 20 (40 μL) | 200 μL |
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| DGCR8-CRKL-20-AQGR | 20 (40 μL) | 200 μL |
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| DGCR8-CRKL-20-AQAQ | 20 (40 μL) | 200 μL |
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CRKL Gene Summary
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]
Gene Name: CRK Like Proto-oncogene, Adaptor Protein
Chromosome: CHR22: 21271713 -21308037
Locus: 22q11.21
DGCR8 Gene Summary
This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Gene Name: DGCR8, Microprocessor Complex Subunit
Chromosome: CHR22: 20067754 -20099400
Locus: 22q11.21
Gene Diseases
The DGCR8 CRKL Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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