DGCR8-COMT Fusion FISH Probe
The DGCR8-COMT Fusion FISH Probe is used to confirm a fusion of the DGCR8 and COMT genes. The fusion of the DGCR8 and COMT genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DGCR8-COMT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DGCR8-COMT-20-RERE | 20 (40 μL) | 200 μL |
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| DGCR8-COMT-20-REOR | 20 (40 μL) | 200 μL |
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| DGCR8-COMT-20-REGO | 20 (40 μL) | 200 μL |
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| DGCR8-COMT-20-REGR | 20 (40 μL) | 200 μL |
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| DGCR8-COMT-20-REAQ | 20 (40 μL) | 200 μL |
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| DGCR8-COMT-20-ORRE | 20 (40 μL) | 200 μL |
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| DGCR8-COMT-20-OROR | 20 (40 μL) | 200 μL |
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| DGCR8-COMT-20-ORGO | 20 (40 μL) | 200 μL |
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| DGCR8-COMT-20-ORAQ | 20 (40 μL) | 200 μL |
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| DGCR8-COMT-20-GORE | 20 (40 μL) | 200 μL |
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| DGCR8-COMT-20-GOOR | 20 (40 μL) | 200 μL |
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| DGCR8-COMT-20-GOGO | 20 (40 μL) | 200 μL |
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| DGCR8-COMT-20-GOGR | 20 (40 μL) | 200 μL |
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| DGCR8-COMT-20-GOAQ | 20 (40 μL) | 200 μL |
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| DGCR8-COMT-20-GRRE | 20 (40 μL) | 200 μL |
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| DGCR8-COMT-20-GROR | 20 (40 μL) | 200 μL |
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| DGCR8-COMT-20-GRGO | 20 (40 μL) | 200 μL |
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| DGCR8-COMT-20-GRGR | 20 (40 μL) | 200 μL |
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| DGCR8-COMT-20-GRAQ | 20 (40 μL) | 200 μL |
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| DGCR8-COMT-20-AQRE | 20 (40 μL) | 200 μL |
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| DGCR8-COMT-20-AQOR | 20 (40 μL) | 200 μL |
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| DGCR8-COMT-20-AQGO | 20 (40 μL) | 200 μL |
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| DGCR8-COMT-20-AQGR | 20 (40 μL) | 200 μL |
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| DGCR8-COMT-20-AQAQ | 20 (40 μL) | 200 μL |
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COMT Gene Summary
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]
Gene Name: Catechol-O-methyltransferase
Chromosome: CHR22: 19929262 -19957498
Locus: 22q11.21
DGCR8 Gene Summary
This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Gene Name: DGCR8, Microprocessor Complex Subunit
Chromosome: CHR22: 20067754 -20099400
Locus: 22q11.21
Gene Diseases
The DGCR8 COMT Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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