DGCR2-GNB1L Fusion FISH Probe
The DGCR2-GNB1L Fusion FISH Probe is used to confirm a fusion of the DGCR2 and GNB1L genes. The fusion of the DGCR2 and GNB1L genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DGCR2-GNB1L-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DGCR2-GNB1L-20-RERE | 20 (40 μL) | 200 μL |
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| DGCR2-GNB1L-20-REOR | 20 (40 μL) | 200 μL |
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| DGCR2-GNB1L-20-REGO | 20 (40 μL) | 200 μL |
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| DGCR2-GNB1L-20-REGR | 20 (40 μL) | 200 μL |
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| DGCR2-GNB1L-20-REAQ | 20 (40 μL) | 200 μL |
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| DGCR2-GNB1L-20-ORRE | 20 (40 μL) | 200 μL |
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| DGCR2-GNB1L-20-OROR | 20 (40 μL) | 200 μL |
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| DGCR2-GNB1L-20-ORGO | 20 (40 μL) | 200 μL |
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| DGCR2-GNB1L-20-ORAQ | 20 (40 μL) | 200 μL |
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| DGCR2-GNB1L-20-GORE | 20 (40 μL) | 200 μL |
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| DGCR2-GNB1L-20-GOOR | 20 (40 μL) | 200 μL |
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| DGCR2-GNB1L-20-GOGO | 20 (40 μL) | 200 μL |
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| DGCR2-GNB1L-20-GOGR | 20 (40 μL) | 200 μL |
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| DGCR2-GNB1L-20-GOAQ | 20 (40 μL) | 200 μL |
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| DGCR2-GNB1L-20-GRRE | 20 (40 μL) | 200 μL |
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| DGCR2-GNB1L-20-GROR | 20 (40 μL) | 200 μL |
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| DGCR2-GNB1L-20-GRGO | 20 (40 μL) | 200 μL |
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| DGCR2-GNB1L-20-GRGR | 20 (40 μL) | 200 μL |
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| DGCR2-GNB1L-20-GRAQ | 20 (40 μL) | 200 μL |
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| DGCR2-GNB1L-20-AQRE | 20 (40 μL) | 200 μL |
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| DGCR2-GNB1L-20-AQOR | 20 (40 μL) | 200 μL |
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| DGCR2-GNB1L-20-AQGO | 20 (40 μL) | 200 μL |
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| DGCR2-GNB1L-20-AQGR | 20 (40 μL) | 200 μL |
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| DGCR2-GNB1L-20-AQAQ | 20 (40 μL) | 200 μL |
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DGCR2 Gene Summary
Deletions of the 22q11.2 have been associated with a wide range of developmental defects (notably DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome and isolated conotruncal cardiac defects) classified under the acronym CATCH 22. The DGCR2 gene encodes a novel putative adhesion receptor protein, which could play a role in neural crest cells migration, a process which has been proposed to be altered in DiGeorge syndrome. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Name: DiGeorge Syndrome Critical Region Gene 2
Chromosome: CHR22: 19023794 -19109967
Locus: 22q11.21
GNB1L Gene Summary
This gene encodes a G-protein beta-subunit-like polypeptide which is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 6 WD repeats and is highly expressed in the heart. The gene maps to the region on chromosome 22q11, which is deleted in DiGeorge syndrome, trisomic in derivative 22 syndrome and tetrasomic in cat-eye syndrome. Therefore, this gene may contribute to the etiology of those disorders. Transcripts from this gene share exons with some transcripts from the C22orf29 gene. [provided by RefSeq, Jul 2008]
Gene Name: G Protein Subunit Beta 1 Like
Chromosome: CHR22: 19775933 -19842462
Locus: 22q11.21
Gene Diseases
The DGCR2 GNB1L Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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