DERA-LRP6 Fusion FISH Probe
The DERA-LRP6 Fusion FISH Probe is used to confirm a fusion of the DERA and LRP6 genes. The fusion of the DERA and LRP6 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DERA-LRP6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DERA-LRP6-20-RERE | 20 (40 μL) | 200 μL |
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| DERA-LRP6-20-REOR | 20 (40 μL) | 200 μL |
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| DERA-LRP6-20-REGO | 20 (40 μL) | 200 μL |
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| DERA-LRP6-20-REGR | 20 (40 μL) | 200 μL |
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| DERA-LRP6-20-REAQ | 20 (40 μL) | 200 μL |
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| DERA-LRP6-20-ORRE | 20 (40 μL) | 200 μL |
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| DERA-LRP6-20-OROR | 20 (40 μL) | 200 μL |
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| DERA-LRP6-20-ORGO | 20 (40 μL) | 200 μL |
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| DERA-LRP6-20-ORAQ | 20 (40 μL) | 200 μL |
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| DERA-LRP6-20-GORE | 20 (40 μL) | 200 μL |
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| DERA-LRP6-20-GOOR | 20 (40 μL) | 200 μL |
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| DERA-LRP6-20-GOGO | 20 (40 μL) | 200 μL |
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| DERA-LRP6-20-GOGR | 20 (40 μL) | 200 μL |
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| DERA-LRP6-20-GOAQ | 20 (40 μL) | 200 μL |
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| DERA-LRP6-20-GRRE | 20 (40 μL) | 200 μL |
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| DERA-LRP6-20-GROR | 20 (40 μL) | 200 μL |
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| DERA-LRP6-20-GRGO | 20 (40 μL) | 200 μL |
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| DERA-LRP6-20-GRGR | 20 (40 μL) | 200 μL |
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| DERA-LRP6-20-GRAQ | 20 (40 μL) | 200 μL |
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| DERA-LRP6-20-AQRE | 20 (40 μL) | 200 μL |
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| DERA-LRP6-20-AQOR | 20 (40 μL) | 200 μL |
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| DERA-LRP6-20-AQGO | 20 (40 μL) | 200 μL |
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| DERA-LRP6-20-AQGR | 20 (40 μL) | 200 μL |
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| DERA-LRP6-20-AQAQ | 20 (40 μL) | 200 μL |
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LRP6 Gene Summary
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]
Gene Name: LDL Receptor Related Protein 6
Chromosome: CHR12: 12268960 -12419811
Locus: 12p13.2
DERA Gene Summary
The Deoxyribose-phosphate Aldolase (DERA) gene is located on chr12 :16064185-16190315 at 12p12.3.
Gene Name: Deoxyribose-phosphate Aldolase
Chromosome: CHR12: 16064185 -16190315
Locus: 12p12.3
Gene Diseases
The DERA LRP6 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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