DEPDC5-CDH19 Fusion FISH Probe
The DEPDC5-CDH19 Fusion FISH Probe is used to confirm a fusion of the DEPDC5 and CDH19 genes. The fusion of the DEPDC5 and CDH19 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DEPDC5-CDH19-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DEPDC5-CDH19-20-RERE | 20 (40 μL) | 200 μL |
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| DEPDC5-CDH19-20-REOR | 20 (40 μL) | 200 μL |
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| DEPDC5-CDH19-20-REGO | 20 (40 μL) | 200 μL |
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| DEPDC5-CDH19-20-REGR | 20 (40 μL) | 200 μL |
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| DEPDC5-CDH19-20-REAQ | 20 (40 μL) | 200 μL |
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| DEPDC5-CDH19-20-ORRE | 20 (40 μL) | 200 μL |
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| DEPDC5-CDH19-20-OROR | 20 (40 μL) | 200 μL |
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| DEPDC5-CDH19-20-ORGO | 20 (40 μL) | 200 μL |
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| DEPDC5-CDH19-20-ORAQ | 20 (40 μL) | 200 μL |
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| DEPDC5-CDH19-20-GORE | 20 (40 μL) | 200 μL |
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| DEPDC5-CDH19-20-GOOR | 20 (40 μL) | 200 μL |
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| DEPDC5-CDH19-20-GOGO | 20 (40 μL) | 200 μL |
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| DEPDC5-CDH19-20-GOGR | 20 (40 μL) | 200 μL |
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| DEPDC5-CDH19-20-GOAQ | 20 (40 μL) | 200 μL |
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| DEPDC5-CDH19-20-GRRE | 20 (40 μL) | 200 μL |
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| DEPDC5-CDH19-20-GROR | 20 (40 μL) | 200 μL |
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| DEPDC5-CDH19-20-GRGO | 20 (40 μL) | 200 μL |
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| DEPDC5-CDH19-20-GRGR | 20 (40 μL) | 200 μL |
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| DEPDC5-CDH19-20-GRAQ | 20 (40 μL) | 200 μL |
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| DEPDC5-CDH19-20-AQRE | 20 (40 μL) | 200 μL |
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| DEPDC5-CDH19-20-AQOR | 20 (40 μL) | 200 μL |
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| DEPDC5-CDH19-20-AQGO | 20 (40 μL) | 200 μL |
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| DEPDC5-CDH19-20-AQGR | 20 (40 μL) | 200 μL |
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| DEPDC5-CDH19-20-AQAQ | 20 (40 μL) | 200 μL |
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DEPDC5 Gene Summary
This gene encodes a member of the IML1 family of proteins involved in G-protein signaling pathways. The mechanistic target of rapamycin complex 1 (mTORC1) pathway regulates cell growth by sensing the availability of nutrients. The protein encoded by this gene is a component of the GATOR1 (GAP activity toward Rags) complex which inhibits the amino acid-sensing branch of the mTORC1 pathway. Mutations in this gene are associated with autosomal dominant familial focal epilepsy with variable foci. A single nucleotide polymorphism in an intron of this gene has been associated with an increased risk of hepatocellular carcinoma in individuals with chronic hepatitis C virus infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Gene Name: DEP Domain Containing 5
Chromosome: CHR22: 32149936 -32303020
Locus: 22q12.2-q12.3
CDH19 Gene Summary
This gene is one of three related type II cadherin genes situated in a cluster on chromosome 18. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein containing five extracellular cadherin repeats. Loss of cadherins may be associated with cancer formation. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Aug 2012]
Gene Name: Cadherin 19
Chromosome: CHR18: 64171320 -64271216
Locus: 18q22.1
Gene Diseases
The DEPDC5 CDH19 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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