DENND1B-TSPAN31 Fusion FISH Probe
The DENND1B-TSPAN31 Fusion FISH Probe is used to confirm a fusion of the DENND1B and TSPAN31 genes. The fusion of the DENND1B and TSPAN31 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DENND1B-TSPAN31-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DENND1B-TSPAN31-20-RERE | 20 (40 μL) | 200 μL |
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| DENND1B-TSPAN31-20-REOR | 20 (40 μL) | 200 μL |
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| DENND1B-TSPAN31-20-REGO | 20 (40 μL) | 200 μL |
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| DENND1B-TSPAN31-20-REGR | 20 (40 μL) | 200 μL |
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| DENND1B-TSPAN31-20-REAQ | 20 (40 μL) | 200 μL |
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| DENND1B-TSPAN31-20-ORRE | 20 (40 μL) | 200 μL |
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| DENND1B-TSPAN31-20-OROR | 20 (40 μL) | 200 μL |
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| DENND1B-TSPAN31-20-ORGO | 20 (40 μL) | 200 μL |
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| DENND1B-TSPAN31-20-ORAQ | 20 (40 μL) | 200 μL |
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| DENND1B-TSPAN31-20-GORE | 20 (40 μL) | 200 μL |
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| DENND1B-TSPAN31-20-GOOR | 20 (40 μL) | 200 μL |
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| DENND1B-TSPAN31-20-GOGO | 20 (40 μL) | 200 μL |
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| DENND1B-TSPAN31-20-GOGR | 20 (40 μL) | 200 μL |
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| DENND1B-TSPAN31-20-GOAQ | 20 (40 μL) | 200 μL |
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| DENND1B-TSPAN31-20-GRRE | 20 (40 μL) | 200 μL |
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| DENND1B-TSPAN31-20-GROR | 20 (40 μL) | 200 μL |
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| DENND1B-TSPAN31-20-GRGO | 20 (40 μL) | 200 μL |
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| DENND1B-TSPAN31-20-GRGR | 20 (40 μL) | 200 μL |
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| DENND1B-TSPAN31-20-GRAQ | 20 (40 μL) | 200 μL |
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| DENND1B-TSPAN31-20-AQRE | 20 (40 μL) | 200 μL |
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| DENND1B-TSPAN31-20-AQOR | 20 (40 μL) | 200 μL |
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| DENND1B-TSPAN31-20-AQGO | 20 (40 μL) | 200 μL |
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| DENND1B-TSPAN31-20-AQGR | 20 (40 μL) | 200 μL |
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| DENND1B-TSPAN31-20-AQAQ | 20 (40 μL) | 200 μL |
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TSPAN31 Gene Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is thought to be involved in growth-related cellular processes. This gene is associated with tumorigenesis and osteosarcoma. [provided by RefSeq, Jul 2008]
Gene Name: Tetraspanin 31
Chromosome: CHR12: 58138783 -58142026
Locus: 12q14.1
DENND1B Gene Summary
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]
Gene Name: DENN Domain Containing 1B
Chromosome: CHR1: 197473878 -197744623
Locus: 1q31.3
Gene Diseases
The DENND1B TSPAN31 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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