DENND1B-RRP15 Fusion FISH Probe
The DENND1B-RRP15 Fusion FISH Probe is used to confirm a fusion of the DENND1B and RRP15 genes. The fusion of the DENND1B and RRP15 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DENND1B-RRP15-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DENND1B-RRP15-20-RERE | 20 (40 μL) | 200 μL |
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| DENND1B-RRP15-20-REOR | 20 (40 μL) | 200 μL |
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| DENND1B-RRP15-20-REGO | 20 (40 μL) | 200 μL |
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| DENND1B-RRP15-20-REGR | 20 (40 μL) | 200 μL |
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| DENND1B-RRP15-20-REAQ | 20 (40 μL) | 200 μL |
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| DENND1B-RRP15-20-ORRE | 20 (40 μL) | 200 μL |
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| DENND1B-RRP15-20-OROR | 20 (40 μL) | 200 μL |
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| DENND1B-RRP15-20-ORGO | 20 (40 μL) | 200 μL |
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| DENND1B-RRP15-20-ORAQ | 20 (40 μL) | 200 μL |
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| DENND1B-RRP15-20-GORE | 20 (40 μL) | 200 μL |
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| DENND1B-RRP15-20-GOOR | 20 (40 μL) | 200 μL |
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| DENND1B-RRP15-20-GOGO | 20 (40 μL) | 200 μL |
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| DENND1B-RRP15-20-GOGR | 20 (40 μL) | 200 μL |
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| DENND1B-RRP15-20-GOAQ | 20 (40 μL) | 200 μL |
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| DENND1B-RRP15-20-GRRE | 20 (40 μL) | 200 μL |
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| DENND1B-RRP15-20-GROR | 20 (40 μL) | 200 μL |
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| DENND1B-RRP15-20-GRGO | 20 (40 μL) | 200 μL |
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| DENND1B-RRP15-20-GRGR | 20 (40 μL) | 200 μL |
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| DENND1B-RRP15-20-GRAQ | 20 (40 μL) | 200 μL |
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| DENND1B-RRP15-20-AQRE | 20 (40 μL) | 200 μL |
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| DENND1B-RRP15-20-AQOR | 20 (40 μL) | 200 μL |
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| DENND1B-RRP15-20-AQGO | 20 (40 μL) | 200 μL |
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| DENND1B-RRP15-20-AQGR | 20 (40 μL) | 200 μL |
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| DENND1B-RRP15-20-AQAQ | 20 (40 μL) | 200 μL |
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RRP15 Gene Summary
This gene encodes a protein that co-purifies with human nucleoli. A similar protein in budding yeast is a component of pre-60S ribosomal particles, and is required for the early maturation steps of the 60S subunit. [provided by RefSeq, Jul 2008]
Gene Name: Ribosomal RNA Processing 15 Homolog
Chromosome: CHR1: 218458628 -218511325
Locus: 1q41
DENND1B Gene Summary
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]
Gene Name: DENN Domain Containing 1B
Chromosome: CHR1: 197473878 -197744623
Locus: 1q31.3
Gene Diseases
The DENND1B RRP15 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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