DENND1B-CRB1 Fusion FISH Probe
The DENND1B-CRB1 Fusion FISH Probe is used to confirm a fusion of the DENND1B and CRB1 genes. The fusion of the DENND1B and CRB1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DENND1B-CRB1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DENND1B-CRB1-20-RERE | 20 (40 μL) | 200 μL |
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| DENND1B-CRB1-20-REOR | 20 (40 μL) | 200 μL |
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| DENND1B-CRB1-20-REGO | 20 (40 μL) | 200 μL |
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| DENND1B-CRB1-20-REGR | 20 (40 μL) | 200 μL |
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| DENND1B-CRB1-20-REAQ | 20 (40 μL) | 200 μL |
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| DENND1B-CRB1-20-ORRE | 20 (40 μL) | 200 μL |
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| DENND1B-CRB1-20-OROR | 20 (40 μL) | 200 μL |
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| DENND1B-CRB1-20-ORGO | 20 (40 μL) | 200 μL |
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| DENND1B-CRB1-20-ORAQ | 20 (40 μL) | 200 μL |
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| DENND1B-CRB1-20-GORE | 20 (40 μL) | 200 μL |
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| DENND1B-CRB1-20-GOOR | 20 (40 μL) | 200 μL |
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| DENND1B-CRB1-20-GOGO | 20 (40 μL) | 200 μL |
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| DENND1B-CRB1-20-GOGR | 20 (40 μL) | 200 μL |
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| DENND1B-CRB1-20-GOAQ | 20 (40 μL) | 200 μL |
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| DENND1B-CRB1-20-GRRE | 20 (40 μL) | 200 μL |
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| DENND1B-CRB1-20-GROR | 20 (40 μL) | 200 μL |
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| DENND1B-CRB1-20-GRGO | 20 (40 μL) | 200 μL |
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| DENND1B-CRB1-20-GRGR | 20 (40 μL) | 200 μL |
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| DENND1B-CRB1-20-GRAQ | 20 (40 μL) | 200 μL |
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| DENND1B-CRB1-20-AQRE | 20 (40 μL) | 200 μL |
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| DENND1B-CRB1-20-AQOR | 20 (40 μL) | 200 μL |
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| DENND1B-CRB1-20-AQGO | 20 (40 μL) | 200 μL |
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| DENND1B-CRB1-20-AQGR | 20 (40 μL) | 200 μL |
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| DENND1B-CRB1-20-AQAQ | 20 (40 μL) | 200 μL |
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CRB1 Gene Summary
This gene encodes a protein which is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. In Drosophila crumbs localizes to the stalk of the fly photoreceptor and may be a component of the molecular scaffold that controls proper development of polarity in the eye. Mutations in this gene are associated with a severe form of retinitis pigmentosa, RP12, and with Leber congenital amaurosis. Alternate splicing results in multiple transcript variants, some protein coding and some non-protein coding.[provided by RefSeq, Apr 2012]
Gene Name: Crumbs 1, Cell Polarity Complex Component
Chromosome: CHR1: 197237333 -197447585
Locus: 1q31.3
DENND1B Gene Summary
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]
Gene Name: DENN Domain Containing 1B
Chromosome: CHR1: 197473878 -197744623
Locus: 1q31.3
Gene Diseases
The DENND1B CRB1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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