DENND1B-ATP6V1G3 Fusion FISH Probe
The DENND1B-ATP6V1G3 Fusion FISH Probe is used to confirm a fusion of the DENND1B and ATP6V1G3 genes. The fusion of the DENND1B and ATP6V1G3 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DENND1B-ATP6V1G3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DENND1B-ATP6V1G3-20-RERE | 20 (40 μL) | 200 μL |
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| DENND1B-ATP6V1G3-20-REOR | 20 (40 μL) | 200 μL |
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| DENND1B-ATP6V1G3-20-REGO | 20 (40 μL) | 200 μL |
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| DENND1B-ATP6V1G3-20-REGR | 20 (40 μL) | 200 μL |
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| DENND1B-ATP6V1G3-20-REAQ | 20 (40 μL) | 200 μL |
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| DENND1B-ATP6V1G3-20-ORRE | 20 (40 μL) | 200 μL |
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| DENND1B-ATP6V1G3-20-OROR | 20 (40 μL) | 200 μL |
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| DENND1B-ATP6V1G3-20-ORGO | 20 (40 μL) | 200 μL |
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| DENND1B-ATP6V1G3-20-ORAQ | 20 (40 μL) | 200 μL |
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| DENND1B-ATP6V1G3-20-GORE | 20 (40 μL) | 200 μL |
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| DENND1B-ATP6V1G3-20-GOOR | 20 (40 μL) | 200 μL |
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| DENND1B-ATP6V1G3-20-GOGO | 20 (40 μL) | 200 μL |
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| DENND1B-ATP6V1G3-20-GOGR | 20 (40 μL) | 200 μL |
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| DENND1B-ATP6V1G3-20-GOAQ | 20 (40 μL) | 200 μL |
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| DENND1B-ATP6V1G3-20-GRRE | 20 (40 μL) | 200 μL |
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| DENND1B-ATP6V1G3-20-GROR | 20 (40 μL) | 200 μL |
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| DENND1B-ATP6V1G3-20-GRGO | 20 (40 μL) | 200 μL |
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| DENND1B-ATP6V1G3-20-GRGR | 20 (40 μL) | 200 μL |
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| DENND1B-ATP6V1G3-20-GRAQ | 20 (40 μL) | 200 μL |
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| DENND1B-ATP6V1G3-20-AQRE | 20 (40 μL) | 200 μL |
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| DENND1B-ATP6V1G3-20-AQOR | 20 (40 μL) | 200 μL |
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| DENND1B-ATP6V1G3-20-AQGO | 20 (40 μL) | 200 μL |
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| DENND1B-ATP6V1G3-20-AQGR | 20 (40 μL) | 200 μL |
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| DENND1B-ATP6V1G3-20-AQAQ | 20 (40 μL) | 200 μL |
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ATP6V1G3 Gene Summary
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'' and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three G subunit proteins. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: ATPase H+ Transporting V1 Subunit G3
Chromosome: CHR1: 198492351 -198510075
Locus: 1q31.3
DENND1B Gene Summary
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]
Gene Name: DENN Domain Containing 1B
Chromosome: CHR1: 197473878 -197744623
Locus: 1q31.3
Gene Diseases
The DENND1B ATP6V1G3 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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