DENND1A-RRAGB Fusion FISH Probe
The DENND1A-RRAGB Fusion FISH Probe is used to confirm a fusion of the DENND1A and RRAGB genes. The fusion of the DENND1A and RRAGB genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DENND1A-RRAGB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DENND1A-RRAGB-20-RERE | 20 (40 μL) | 200 μL |
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| DENND1A-RRAGB-20-REOR | 20 (40 μL) | 200 μL |
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| DENND1A-RRAGB-20-REGO | 20 (40 μL) | 200 μL |
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| DENND1A-RRAGB-20-REGR | 20 (40 μL) | 200 μL |
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| DENND1A-RRAGB-20-REAQ | 20 (40 μL) | 200 μL |
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| DENND1A-RRAGB-20-ORRE | 20 (40 μL) | 200 μL |
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| DENND1A-RRAGB-20-OROR | 20 (40 μL) | 200 μL |
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| DENND1A-RRAGB-20-ORGO | 20 (40 μL) | 200 μL |
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| DENND1A-RRAGB-20-ORAQ | 20 (40 μL) | 200 μL |
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| DENND1A-RRAGB-20-GORE | 20 (40 μL) | 200 μL |
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| DENND1A-RRAGB-20-GOOR | 20 (40 μL) | 200 μL |
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| DENND1A-RRAGB-20-GOGO | 20 (40 μL) | 200 μL |
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| DENND1A-RRAGB-20-GOGR | 20 (40 μL) | 200 μL |
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| DENND1A-RRAGB-20-GOAQ | 20 (40 μL) | 200 μL |
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| DENND1A-RRAGB-20-GRRE | 20 (40 μL) | 200 μL |
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| DENND1A-RRAGB-20-GROR | 20 (40 μL) | 200 μL |
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| DENND1A-RRAGB-20-GRGO | 20 (40 μL) | 200 μL |
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| DENND1A-RRAGB-20-GRGR | 20 (40 μL) | 200 μL |
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| DENND1A-RRAGB-20-GRAQ | 20 (40 μL) | 200 μL |
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| DENND1A-RRAGB-20-AQRE | 20 (40 μL) | 200 μL |
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| DENND1A-RRAGB-20-AQOR | 20 (40 μL) | 200 μL |
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| DENND1A-RRAGB-20-AQGO | 20 (40 μL) | 200 μL |
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| DENND1A-RRAGB-20-AQGR | 20 (40 μL) | 200 μL |
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| DENND1A-RRAGB-20-AQAQ | 20 (40 μL) | 200 μL |
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RRAGB Gene Summary
Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Ras Related GTP Binding B
Chromosome: CHRX: 55744109 -55785207
Locus: Xp11.21
DENND1A Gene Summary
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]
Gene Name: DENN Domain Containing 1A
Chromosome: CHR9: 126141932 -126692417
Locus: 9q33.3
Gene Diseases
The DENND1A RRAGB Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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