DENND1A-PSMB7 Fusion FISH Probe
The DENND1A-PSMB7 Fusion FISH Probe is used to confirm a fusion of the DENND1A and PSMB7 genes. The fusion of the DENND1A and PSMB7 genes has been associated with Uterine Corpus Endometrial Carcinoma, Skin Cutaneous Melanoma, and Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DENND1A-PSMB7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DENND1A-PSMB7-20-RERE | 20 (40 μL) | 200 μL |
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| DENND1A-PSMB7-20-REOR | 20 (40 μL) | 200 μL |
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| DENND1A-PSMB7-20-REGO | 20 (40 μL) | 200 μL |
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| DENND1A-PSMB7-20-REGR | 20 (40 μL) | 200 μL |
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| DENND1A-PSMB7-20-REAQ | 20 (40 μL) | 200 μL |
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| DENND1A-PSMB7-20-ORRE | 20 (40 μL) | 200 μL |
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| DENND1A-PSMB7-20-OROR | 20 (40 μL) | 200 μL |
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| DENND1A-PSMB7-20-ORGO | 20 (40 μL) | 200 μL |
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| DENND1A-PSMB7-20-ORAQ | 20 (40 μL) | 200 μL |
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| DENND1A-PSMB7-20-GORE | 20 (40 μL) | 200 μL |
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| DENND1A-PSMB7-20-GOOR | 20 (40 μL) | 200 μL |
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| DENND1A-PSMB7-20-GOGO | 20 (40 μL) | 200 μL |
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| DENND1A-PSMB7-20-GOGR | 20 (40 μL) | 200 μL |
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| DENND1A-PSMB7-20-GOAQ | 20 (40 μL) | 200 μL |
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| DENND1A-PSMB7-20-GRRE | 20 (40 μL) | 200 μL |
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| DENND1A-PSMB7-20-GROR | 20 (40 μL) | 200 μL |
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| DENND1A-PSMB7-20-GRGO | 20 (40 μL) | 200 μL |
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| DENND1A-PSMB7-20-GRGR | 20 (40 μL) | 200 μL |
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| DENND1A-PSMB7-20-GRAQ | 20 (40 μL) | 200 μL |
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| DENND1A-PSMB7-20-AQRE | 20 (40 μL) | 200 μL |
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| DENND1A-PSMB7-20-AQOR | 20 (40 μL) | 200 μL |
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| DENND1A-PSMB7-20-AQGO | 20 (40 μL) | 200 μL |
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| DENND1A-PSMB7-20-AQGR | 20 (40 μL) | 200 μL |
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| DENND1A-PSMB7-20-AQAQ | 20 (40 μL) | 200 μL |
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PSMB7 Gene Summary
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon, and proteolytic processing is required to generate a mature subunit. A pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Jul 2012]
Gene Name: Proteasome Subunit Beta 7
Chromosome: CHR9: 127115743 -127177721
Locus: 9q33.3
DENND1A Gene Summary
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]
Gene Name: DENN Domain Containing 1A
Chromosome: CHR9: 126141932 -126692417
Locus: 9q33.3
Gene Diseases
The DENND1A PSMB7 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
| Skin Cutaneous Melanoma |
| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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