DENND1A-PRRX2 Fusion FISH Probe
The DENND1A-PRRX2 Fusion FISH Probe is used to confirm a fusion of the DENND1A and PRRX2 genes. The fusion of the DENND1A and PRRX2 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DENND1A-PRRX2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DENND1A-PRRX2-20-RERE | 20 (40 μL) | 200 μL |
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| DENND1A-PRRX2-20-REOR | 20 (40 μL) | 200 μL |
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| DENND1A-PRRX2-20-REGO | 20 (40 μL) | 200 μL |
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| DENND1A-PRRX2-20-REGR | 20 (40 μL) | 200 μL |
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| DENND1A-PRRX2-20-REAQ | 20 (40 μL) | 200 μL |
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| DENND1A-PRRX2-20-ORRE | 20 (40 μL) | 200 μL |
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| DENND1A-PRRX2-20-OROR | 20 (40 μL) | 200 μL |
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| DENND1A-PRRX2-20-ORGO | 20 (40 μL) | 200 μL |
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| DENND1A-PRRX2-20-ORAQ | 20 (40 μL) | 200 μL |
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| DENND1A-PRRX2-20-GORE | 20 (40 μL) | 200 μL |
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| DENND1A-PRRX2-20-GOOR | 20 (40 μL) | 200 μL |
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| DENND1A-PRRX2-20-GOGO | 20 (40 μL) | 200 μL |
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| DENND1A-PRRX2-20-GOGR | 20 (40 μL) | 200 μL |
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| DENND1A-PRRX2-20-GOAQ | 20 (40 μL) | 200 μL |
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| DENND1A-PRRX2-20-GRRE | 20 (40 μL) | 200 μL |
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| DENND1A-PRRX2-20-GROR | 20 (40 μL) | 200 μL |
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| DENND1A-PRRX2-20-GRGO | 20 (40 μL) | 200 μL |
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| DENND1A-PRRX2-20-GRGR | 20 (40 μL) | 200 μL |
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| DENND1A-PRRX2-20-GRAQ | 20 (40 μL) | 200 μL |
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| DENND1A-PRRX2-20-AQRE | 20 (40 μL) | 200 μL |
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| DENND1A-PRRX2-20-AQOR | 20 (40 μL) | 200 μL |
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| DENND1A-PRRX2-20-AQGO | 20 (40 μL) | 200 μL |
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| DENND1A-PRRX2-20-AQGR | 20 (40 μL) | 200 μL |
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| DENND1A-PRRX2-20-AQAQ | 20 (40 μL) | 200 μL |
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PRRX2 Gene Summary
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation. [provided by RefSeq, Jul 2008]
Gene Name: Paired Related Homeobox 2
Chromosome: CHR9: 132427919 -132484951
Locus: 9q34.11
DENND1A Gene Summary
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]
Gene Name: DENN Domain Containing 1A
Chromosome: CHR9: 126141932 -126692417
Locus: 9q33.3
Gene Diseases
The DENND1A PRRX2 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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