DENND1A-ENG Fusion FISH Probe
The DENND1A-ENG Fusion FISH Probe is used to confirm a fusion of the DENND1A and ENG genes. The fusion of the DENND1A and ENG genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DENND1A-ENG-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DENND1A-ENG-20-RERE | 20 (40 μL) | 200 μL |
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| DENND1A-ENG-20-REOR | 20 (40 μL) | 200 μL |
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| DENND1A-ENG-20-REGO | 20 (40 μL) | 200 μL |
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| DENND1A-ENG-20-REGR | 20 (40 μL) | 200 μL |
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| DENND1A-ENG-20-REAQ | 20 (40 μL) | 200 μL |
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| DENND1A-ENG-20-ORRE | 20 (40 μL) | 200 μL |
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| DENND1A-ENG-20-OROR | 20 (40 μL) | 200 μL |
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| DENND1A-ENG-20-ORGO | 20 (40 μL) | 200 μL |
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| DENND1A-ENG-20-ORAQ | 20 (40 μL) | 200 μL |
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| DENND1A-ENG-20-GORE | 20 (40 μL) | 200 μL |
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| DENND1A-ENG-20-GOOR | 20 (40 μL) | 200 μL |
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| DENND1A-ENG-20-GOGO | 20 (40 μL) | 200 μL |
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| DENND1A-ENG-20-GOGR | 20 (40 μL) | 200 μL |
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| DENND1A-ENG-20-GOAQ | 20 (40 μL) | 200 μL |
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| DENND1A-ENG-20-GRRE | 20 (40 μL) | 200 μL |
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| DENND1A-ENG-20-GROR | 20 (40 μL) | 200 μL |
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| DENND1A-ENG-20-GRGO | 20 (40 μL) | 200 μL |
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| DENND1A-ENG-20-GRGR | 20 (40 μL) | 200 μL |
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| DENND1A-ENG-20-GRAQ | 20 (40 μL) | 200 μL |
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| DENND1A-ENG-20-AQRE | 20 (40 μL) | 200 μL |
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| DENND1A-ENG-20-AQOR | 20 (40 μL) | 200 μL |
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| DENND1A-ENG-20-AQGO | 20 (40 μL) | 200 μL |
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| DENND1A-ENG-20-AQGR | 20 (40 μL) | 200 μL |
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| DENND1A-ENG-20-AQAQ | 20 (40 μL) | 200 μL |
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ENG Gene Summary
This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]
Gene Name: Endoglin
Chromosome: CHR9: 130577290 -130617047
Locus: 9q34.11
DENND1A Gene Summary
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]
Gene Name: DENN Domain Containing 1A
Chromosome: CHR9: 126141932 -126692417
Locus: 9q33.3
Gene Diseases
The DENND1A ENG Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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