DENND1A-ASTN2 Fusion FISH Probe
The DENND1A-ASTN2 Fusion FISH Probe is used to confirm a fusion of the DENND1A and ASTN2 genes. The fusion of the DENND1A and ASTN2 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DENND1A-ASTN2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DENND1A-ASTN2-20-RERE | 20 (40 μL) | 200 μL |
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| DENND1A-ASTN2-20-REOR | 20 (40 μL) | 200 μL |
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| DENND1A-ASTN2-20-REGO | 20 (40 μL) | 200 μL |
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| DENND1A-ASTN2-20-REGR | 20 (40 μL) | 200 μL |
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| DENND1A-ASTN2-20-REAQ | 20 (40 μL) | 200 μL |
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| DENND1A-ASTN2-20-ORRE | 20 (40 μL) | 200 μL |
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| DENND1A-ASTN2-20-OROR | 20 (40 μL) | 200 μL |
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| DENND1A-ASTN2-20-ORGO | 20 (40 μL) | 200 μL |
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| DENND1A-ASTN2-20-ORAQ | 20 (40 μL) | 200 μL |
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| DENND1A-ASTN2-20-GORE | 20 (40 μL) | 200 μL |
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| DENND1A-ASTN2-20-GOOR | 20 (40 μL) | 200 μL |
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| DENND1A-ASTN2-20-GOGO | 20 (40 μL) | 200 μL |
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| DENND1A-ASTN2-20-GOGR | 20 (40 μL) | 200 μL |
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| DENND1A-ASTN2-20-GOAQ | 20 (40 μL) | 200 μL |
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| DENND1A-ASTN2-20-GRRE | 20 (40 μL) | 200 μL |
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| DENND1A-ASTN2-20-GROR | 20 (40 μL) | 200 μL |
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| DENND1A-ASTN2-20-GRGO | 20 (40 μL) | 200 μL |
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| DENND1A-ASTN2-20-GRGR | 20 (40 μL) | 200 μL |
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| DENND1A-ASTN2-20-GRAQ | 20 (40 μL) | 200 μL |
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| DENND1A-ASTN2-20-AQRE | 20 (40 μL) | 200 μL |
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| DENND1A-ASTN2-20-AQOR | 20 (40 μL) | 200 μL |
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| DENND1A-ASTN2-20-AQGO | 20 (40 μL) | 200 μL |
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| DENND1A-ASTN2-20-AQGR | 20 (40 μL) | 200 μL |
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| DENND1A-ASTN2-20-AQAQ | 20 (40 μL) | 200 μL |
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ASTN2 Gene Summary
This gene encodes a protein that is expressed in the brain and may function in neuronal migration, based on functional studies of the related astrotactin 1 gene in human and mouse. A deletion at this locus has been associated with schizophrenia. Multiple transcript variants encoding different proteins have been found for this locus. [provided by RefSeq, May 2010]
Gene Name: Astrotactin 2
Chromosome: CHR9: 119187503 -120177317
Locus: 9q33.1
DENND1A Gene Summary
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]
Gene Name: DENN Domain Containing 1A
Chromosome: CHR9: 126141932 -126692417
Locus: 9q33.3
Gene Diseases
The DENND1A ASTN2 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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