DDX60L-CPE Fusion FISH Probe
The DDX60L-CPE Fusion FISH Probe is used to confirm a fusion of the DDX60L and CPE genes. The fusion of the DDX60L and CPE genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DDX60L-CPE-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DDX60L-CPE-20-RERE | 20 (40 μL) | 200 μL |
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| DDX60L-CPE-20-REOR | 20 (40 μL) | 200 μL |
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| DDX60L-CPE-20-REGO | 20 (40 μL) | 200 μL |
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| DDX60L-CPE-20-REGR | 20 (40 μL) | 200 μL |
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| DDX60L-CPE-20-REAQ | 20 (40 μL) | 200 μL |
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| DDX60L-CPE-20-ORRE | 20 (40 μL) | 200 μL |
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| DDX60L-CPE-20-OROR | 20 (40 μL) | 200 μL |
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| DDX60L-CPE-20-ORGO | 20 (40 μL) | 200 μL |
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| DDX60L-CPE-20-ORAQ | 20 (40 μL) | 200 μL |
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| DDX60L-CPE-20-GORE | 20 (40 μL) | 200 μL |
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| DDX60L-CPE-20-GOOR | 20 (40 μL) | 200 μL |
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| DDX60L-CPE-20-GOGO | 20 (40 μL) | 200 μL |
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| DDX60L-CPE-20-GOGR | 20 (40 μL) | 200 μL |
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| DDX60L-CPE-20-GOAQ | 20 (40 μL) | 200 μL |
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| DDX60L-CPE-20-GRRE | 20 (40 μL) | 200 μL |
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| DDX60L-CPE-20-GROR | 20 (40 μL) | 200 μL |
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| DDX60L-CPE-20-GRGO | 20 (40 μL) | 200 μL |
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| DDX60L-CPE-20-GRGR | 20 (40 μL) | 200 μL |
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| DDX60L-CPE-20-GRAQ | 20 (40 μL) | 200 μL |
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| DDX60L-CPE-20-AQRE | 20 (40 μL) | 200 μL |
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| DDX60L-CPE-20-AQOR | 20 (40 μL) | 200 μL |
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| DDX60L-CPE-20-AQGO | 20 (40 μL) | 200 μL |
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| DDX60L-CPE-20-AQGR | 20 (40 μL) | 200 μL |
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| DDX60L-CPE-20-AQAQ | 20 (40 μL) | 200 μL |
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CPE Gene Summary
This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015]
Gene Name: Carboxypeptidase E
Chromosome: CHR4: 166300096 -166419482
Locus: 4q32.3
DDX60L Gene Summary
This gene encodes a member of the DExD/H-box helicase family of proteins, a subset of the super family 2 helicases. Members of the DExD/H-box helicase family share a conserved functional core comprised of two RecA-like globular domains. These domains contain conserved motifs that mediate ATP binding, ATP hydrolysis, nucleic acid binding, and RNA unwinding. In addition to functions in RNA metabolism, members of this family are involved in anti-viral immunity and act as cytosolic sensors of viral nucleic acids. The protein encoded by this gene has been shown to inhibit hepatitis C virus replication in response to interferon stimulation in cell culture. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Gene Name: DExD/H-box 60 Like
Chromosome: CHR4: 169277885 -169401638
Locus: 4q32.3
Gene Diseases
The DDX60L CPE Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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