DDX46-SEC24A Fusion FISH Probe
The DDX46-SEC24A Fusion FISH Probe is used to confirm a fusion of the DDX46 and SEC24A genes. The fusion of the DDX46 and SEC24A genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DDX46-SEC24A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DDX46-SEC24A-20-RERE | 20 (40 μL) | 200 μL |
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| DDX46-SEC24A-20-REOR | 20 (40 μL) | 200 μL |
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| DDX46-SEC24A-20-REGO | 20 (40 μL) | 200 μL |
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| DDX46-SEC24A-20-REGR | 20 (40 μL) | 200 μL |
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| DDX46-SEC24A-20-REAQ | 20 (40 μL) | 200 μL |
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| DDX46-SEC24A-20-ORRE | 20 (40 μL) | 200 μL |
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| DDX46-SEC24A-20-OROR | 20 (40 μL) | 200 μL |
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| DDX46-SEC24A-20-ORGO | 20 (40 μL) | 200 μL |
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| DDX46-SEC24A-20-ORAQ | 20 (40 μL) | 200 μL |
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| DDX46-SEC24A-20-GORE | 20 (40 μL) | 200 μL |
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| DDX46-SEC24A-20-GOOR | 20 (40 μL) | 200 μL |
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| DDX46-SEC24A-20-GOGO | 20 (40 μL) | 200 μL |
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| DDX46-SEC24A-20-GOGR | 20 (40 μL) | 200 μL |
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| DDX46-SEC24A-20-GOAQ | 20 (40 μL) | 200 μL |
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| DDX46-SEC24A-20-GRRE | 20 (40 μL) | 200 μL |
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| DDX46-SEC24A-20-GROR | 20 (40 μL) | 200 μL |
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| DDX46-SEC24A-20-GRGO | 20 (40 μL) | 200 μL |
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| DDX46-SEC24A-20-GRGR | 20 (40 μL) | 200 μL |
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| DDX46-SEC24A-20-GRAQ | 20 (40 μL) | 200 μL |
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| DDX46-SEC24A-20-AQRE | 20 (40 μL) | 200 μL |
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| DDX46-SEC24A-20-AQOR | 20 (40 μL) | 200 μL |
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| DDX46-SEC24A-20-AQGO | 20 (40 μL) | 200 μL |
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| DDX46-SEC24A-20-AQGR | 20 (40 μL) | 200 μL |
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| DDX46-SEC24A-20-AQAQ | 20 (40 μL) | 200 μL |
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DDX46 Gene Summary
This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the 17S U2 snRNP complex; it plays an important role in pre-mRNA splicing. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2014]
Gene Name: DEAD-box Helicase 46
Chromosome: CHR5: 134094460 -134166812
Locus: 5q31.1
SEC24A Gene Summary
The protein encoded by this gene belongs to a family of proteins that are homologous to yeast Sec24. This protein is a component of coat protein II (COPII)-coated vesicles that mediate protein transport from the endoplasmic reticulum. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Name: SEC24 Homolog A, COPII Coat Complex Component
Chromosome: CHR5: 133984478 -134063601
Locus: 5q31.1
Gene Diseases
The DDX46 SEC24A Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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