DDX23-ARF3 Fusion FISH Probe
The DDX23-ARF3 Fusion FISH Probe is used to confirm a fusion of the DDX23 and ARF3 genes. The fusion of the DDX23 and ARF3 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DDX23-ARF3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DDX23-ARF3-20-RERE | 20 (40 μL) | 200 μL |
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| DDX23-ARF3-20-REOR | 20 (40 μL) | 200 μL |
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| DDX23-ARF3-20-REGO | 20 (40 μL) | 200 μL |
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| DDX23-ARF3-20-REGR | 20 (40 μL) | 200 μL |
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| DDX23-ARF3-20-REAQ | 20 (40 μL) | 200 μL |
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| DDX23-ARF3-20-ORRE | 20 (40 μL) | 200 μL |
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| DDX23-ARF3-20-OROR | 20 (40 μL) | 200 μL |
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| DDX23-ARF3-20-ORGO | 20 (40 μL) | 200 μL |
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| DDX23-ARF3-20-ORAQ | 20 (40 μL) | 200 μL |
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| DDX23-ARF3-20-GORE | 20 (40 μL) | 200 μL |
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| DDX23-ARF3-20-GOOR | 20 (40 μL) | 200 μL |
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| DDX23-ARF3-20-GOGO | 20 (40 μL) | 200 μL |
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| DDX23-ARF3-20-GOGR | 20 (40 μL) | 200 μL |
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| DDX23-ARF3-20-GOAQ | 20 (40 μL) | 200 μL |
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| DDX23-ARF3-20-GRRE | 20 (40 μL) | 200 μL |
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| DDX23-ARF3-20-GROR | 20 (40 μL) | 200 μL |
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| DDX23-ARF3-20-GRGO | 20 (40 μL) | 200 μL |
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| DDX23-ARF3-20-GRGR | 20 (40 μL) | 200 μL |
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| DDX23-ARF3-20-GRAQ | 20 (40 μL) | 200 μL |
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| DDX23-ARF3-20-AQRE | 20 (40 μL) | 200 μL |
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| DDX23-ARF3-20-AQOR | 20 (40 μL) | 200 μL |
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| DDX23-ARF3-20-AQGO | 20 (40 μL) | 200 μL |
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| DDX23-ARF3-20-AQGR | 20 (40 μL) | 200 μL |
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| DDX23-ARF3-20-AQAQ | 20 (40 μL) | 200 μL |
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ARF3 Gene Summary
ADP-ribosylation factor 3 (ARF3) is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6) and members of each class share a common gene organization. The ARF3 gene contains five exons and four introns. [provided by RefSeq, Jul 2008]
Gene Name: ADP Ribosylation Factor 3
Chromosome: CHR12: 49329991 -49351252
Locus: 12q13.12
DDX23 Gene Summary
This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the U5 snRNP complex; it may facilitate conformational changes in the spliceosome during nuclear pre-mRNA splicing. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: DEAD-box Helicase 23
Chromosome: CHR12: 49223538 -49245957
Locus: 12q13.12
Gene Diseases
The DDX23 ARF3 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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