DDX10-ARNTL Fusion FISH Probe
The DDX10-ARNTL Fusion FISH Probe is used to confirm a fusion of the DDX10 and ARNTL genes. The fusion of the DDX10 and ARNTL genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DDX10-ARNTL-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DDX10-ARNTL-20-RERE | 20 (40 μL) | 200 μL |
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| DDX10-ARNTL-20-REOR | 20 (40 μL) | 200 μL |
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| DDX10-ARNTL-20-REGO | 20 (40 μL) | 200 μL |
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| DDX10-ARNTL-20-REGR | 20 (40 μL) | 200 μL |
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| DDX10-ARNTL-20-REAQ | 20 (40 μL) | 200 μL |
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| DDX10-ARNTL-20-ORRE | 20 (40 μL) | 200 μL |
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| DDX10-ARNTL-20-OROR | 20 (40 μL) | 200 μL |
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| DDX10-ARNTL-20-ORGO | 20 (40 μL) | 200 μL |
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| DDX10-ARNTL-20-ORAQ | 20 (40 μL) | 200 μL |
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| DDX10-ARNTL-20-GORE | 20 (40 μL) | 200 μL |
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| DDX10-ARNTL-20-GOOR | 20 (40 μL) | 200 μL |
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| DDX10-ARNTL-20-GOGO | 20 (40 μL) | 200 μL |
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| DDX10-ARNTL-20-GOGR | 20 (40 μL) | 200 μL |
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| DDX10-ARNTL-20-GOAQ | 20 (40 μL) | 200 μL |
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| DDX10-ARNTL-20-GRRE | 20 (40 μL) | 200 μL |
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| DDX10-ARNTL-20-GROR | 20 (40 μL) | 200 μL |
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| DDX10-ARNTL-20-GRGO | 20 (40 μL) | 200 μL |
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| DDX10-ARNTL-20-GRGR | 20 (40 μL) | 200 μL |
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| DDX10-ARNTL-20-GRAQ | 20 (40 μL) | 200 μL |
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| DDX10-ARNTL-20-AQRE | 20 (40 μL) | 200 μL |
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| DDX10-ARNTL-20-AQOR | 20 (40 μL) | 200 μL |
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| DDX10-ARNTL-20-AQGO | 20 (40 μL) | 200 μL |
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| DDX10-ARNTL-20-AQGR | 20 (40 μL) | 200 μL |
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| DDX10-ARNTL-20-AQAQ | 20 (40 μL) | 200 μL |
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ARNTL Gene Summary
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Gene Name: Aryl Hydrocarbon Receptor Nuclear Translocator Like
Chromosome: CHR11: 13299324 -13408812
Locus: 11p15.3
DDX10 Gene Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it may be involved in ribosome assembly. Fusion of this gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. [provided by RefSeq, Jul 2008]
Gene Name: DEAD-box Helicase 10
Chromosome: CHR11: 108535815 -108811648
Locus: 11q22.3
Gene Diseases
The DDX10 ARNTL Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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