DDIT3-GLI1 Fusion FISH Probe
The DDIT3-GLI1 Fusion FISH Probe is used to confirm a fusion of the DDIT3 and GLI1 genes. The fusion of the DDIT3 and GLI1 genes has been associated with Glioblastoma Multiforme. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DDIT3-GLI1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DDIT3-GLI1-20-RERE | 20 (40 μL) | 200 μL |
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| DDIT3-GLI1-20-REOR | 20 (40 μL) | 200 μL |
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| DDIT3-GLI1-20-REGO | 20 (40 μL) | 200 μL |
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| DDIT3-GLI1-20-REGR | 20 (40 μL) | 200 μL |
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| DDIT3-GLI1-20-REAQ | 20 (40 μL) | 200 μL |
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| DDIT3-GLI1-20-ORRE | 20 (40 μL) | 200 μL |
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| DDIT3-GLI1-20-OROR | 20 (40 μL) | 200 μL |
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| DDIT3-GLI1-20-ORGO | 20 (40 μL) | 200 μL |
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| DDIT3-GLI1-20-ORAQ | 20 (40 μL) | 200 μL |
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| DDIT3-GLI1-20-GORE | 20 (40 μL) | 200 μL |
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| DDIT3-GLI1-20-GOOR | 20 (40 μL) | 200 μL |
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| DDIT3-GLI1-20-GOGO | 20 (40 μL) | 200 μL |
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| DDIT3-GLI1-20-GOGR | 20 (40 μL) | 200 μL |
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| DDIT3-GLI1-20-GOAQ | 20 (40 μL) | 200 μL |
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| DDIT3-GLI1-20-GRRE | 20 (40 μL) | 200 μL |
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| DDIT3-GLI1-20-GROR | 20 (40 μL) | 200 μL |
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| DDIT3-GLI1-20-GRGO | 20 (40 μL) | 200 μL |
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| DDIT3-GLI1-20-GRGR | 20 (40 μL) | 200 μL |
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| DDIT3-GLI1-20-GRAQ | 20 (40 μL) | 200 μL |
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| DDIT3-GLI1-20-AQRE | 20 (40 μL) | 200 μL |
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| DDIT3-GLI1-20-AQOR | 20 (40 μL) | 200 μL |
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| DDIT3-GLI1-20-AQGO | 20 (40 μL) | 200 μL |
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| DDIT3-GLI1-20-AQGR | 20 (40 μL) | 200 μL |
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| DDIT3-GLI1-20-AQAQ | 20 (40 μL) | 200 μL |
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DDIT3 Gene Summary
This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010]
Gene Name: DNA Damage Inducible Transcript 3
Chromosome: CHR12: 57910370 -57914300
Locus: 12q13.3
GLI1 Gene Summary
This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Gene Name: GLI Family Zinc Finger 1
Chromosome: CHR12: 57853917 -57866047
Locus: 12q13.3
Gene Diseases
The DDIT3 GLI1 Fusion has been associated with the following diseases:
| Disease Name |
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| Glioblastoma Multiforme |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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