DDB1-CPSF7 Fusion FISH Probe
The DDB1-CPSF7 Fusion FISH Probe is used to confirm a fusion of the DDB1 and CPSF7 genes. The fusion of the DDB1 and CPSF7 genes has been associated with Liver Hepatocellular Carcinoma, and Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DDB1-CPSF7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DDB1-CPSF7-20-RERE | 20 (40 μL) | 200 μL |
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| DDB1-CPSF7-20-REOR | 20 (40 μL) | 200 μL |
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| DDB1-CPSF7-20-REGO | 20 (40 μL) | 200 μL |
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| DDB1-CPSF7-20-REGR | 20 (40 μL) | 200 μL |
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| DDB1-CPSF7-20-REAQ | 20 (40 μL) | 200 μL |
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| DDB1-CPSF7-20-ORRE | 20 (40 μL) | 200 μL |
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| DDB1-CPSF7-20-OROR | 20 (40 μL) | 200 μL |
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| DDB1-CPSF7-20-ORGO | 20 (40 μL) | 200 μL |
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| DDB1-CPSF7-20-ORAQ | 20 (40 μL) | 200 μL |
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| DDB1-CPSF7-20-GORE | 20 (40 μL) | 200 μL |
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| DDB1-CPSF7-20-GOOR | 20 (40 μL) | 200 μL |
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| DDB1-CPSF7-20-GOGO | 20 (40 μL) | 200 μL |
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| DDB1-CPSF7-20-GOGR | 20 (40 μL) | 200 μL |
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| DDB1-CPSF7-20-GOAQ | 20 (40 μL) | 200 μL |
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| DDB1-CPSF7-20-GRRE | 20 (40 μL) | 200 μL |
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| DDB1-CPSF7-20-GROR | 20 (40 μL) | 200 μL |
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| DDB1-CPSF7-20-GRGO | 20 (40 μL) | 200 μL |
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| DDB1-CPSF7-20-GRGR | 20 (40 μL) | 200 μL |
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| DDB1-CPSF7-20-GRAQ | 20 (40 μL) | 200 μL |
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| DDB1-CPSF7-20-AQRE | 20 (40 μL) | 200 μL |
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| DDB1-CPSF7-20-AQOR | 20 (40 μL) | 200 μL |
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| DDB1-CPSF7-20-AQGO | 20 (40 μL) | 200 μL |
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| DDB1-CPSF7-20-AQGR | 20 (40 μL) | 200 μL |
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| DDB1-CPSF7-20-AQAQ | 20 (40 μL) | 200 μL |
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DDB1 Gene Summary
The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins. [provided by RefSeq, May 2012]
Gene Name: Damage Specific DNA Binding Protein 1
Chromosome: CHR11: 61066918 -61100666
Locus: 11q12.2
CPSF7 Gene Summary
Cleavage factor Im (CFIm) is one of six factors necessary for correct cleavage and polyadenylation of pre-mRNAs. CFIm is composed of three different subunits of 25, 59, and 68 kDa, and it functions as a heterotetramer, with a dimer of the 25 kDa subunit binding to two of the 59 or 68 kDa subunits. The protein encoded by this gene represents the 59 kDa subunit, which can interact with the splicing factor U2 snRNP Auxiliary Factor (U2AF) 65 to link the splicing and polyadenylation complexes. [provided by RefSeq, Oct 2016]
Gene Name: Cleavage And Polyadenylation Specific Factor 7
Chromosome: CHR11: 61170119 -61197464
Locus: 11q12.2
Gene Diseases
The DDB1 CPSF7 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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