SEARCH OUR PRODUCT CATALOG

DCUN1D4-IKZF1 Fusion FISH Probe

The DCUN1D4-IKZF1 Fusion FISH Probe is used to confirm a fusion of the DCUN1D4 and IKZF1 genes. The fusion of the DCUN1D4 and IKZF1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
DCUN1D4-IKZF1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
DCUN1D4-IKZF1-20-RERE 20 (40 μL) 200 μL
DCUN1D4-IKZF1-20-REOR 20 (40 μL) 200 μL
DCUN1D4-IKZF1-20-REGO 20 (40 μL) 200 μL
DCUN1D4-IKZF1-20-REGR 20 (40 μL) 200 μL
DCUN1D4-IKZF1-20-REAQ 20 (40 μL) 200 μL
DCUN1D4-IKZF1-20-ORRE 20 (40 μL) 200 μL
DCUN1D4-IKZF1-20-OROR 20 (40 μL) 200 μL
DCUN1D4-IKZF1-20-ORGO 20 (40 μL) 200 μL
DCUN1D4-IKZF1-20-ORAQ 20 (40 μL) 200 μL
DCUN1D4-IKZF1-20-GORE 20 (40 μL) 200 μL
DCUN1D4-IKZF1-20-GOOR 20 (40 μL) 200 μL
DCUN1D4-IKZF1-20-GOGO 20 (40 μL) 200 μL
DCUN1D4-IKZF1-20-GOGR 20 (40 μL) 200 μL
DCUN1D4-IKZF1-20-GOAQ 20 (40 μL) 200 μL
DCUN1D4-IKZF1-20-GRRE 20 (40 μL) 200 μL
DCUN1D4-IKZF1-20-GROR 20 (40 μL) 200 μL
DCUN1D4-IKZF1-20-GRGO 20 (40 μL) 200 μL
DCUN1D4-IKZF1-20-GRGR 20 (40 μL) 200 μL
DCUN1D4-IKZF1-20-GRAQ 20 (40 μL) 200 μL
DCUN1D4-IKZF1-20-AQRE 20 (40 μL) 200 μL
DCUN1D4-IKZF1-20-AQOR 20 (40 μL) 200 μL
DCUN1D4-IKZF1-20-AQGO 20 (40 μL) 200 μL
DCUN1D4-IKZF1-20-AQGR 20 (40 μL) 200 μL
DCUN1D4-IKZF1-20-AQAQ 20 (40 μL) 200 μL

IKZF1 Gene Summary

This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014]

Gene Name: IKAROS Family Zinc Finger 1

Chromosome: CHR7: 50344377 -50472798

Locus: 7p12.2

DCUN1D4 Gene Summary

The Defective In Cullin Neddylation 1 Domain Containing 4 (DCUN1D4) gene is located on chr4 :52709275-52783003 at 4q12.

Gene Name: Defective In Cullin Neddylation 1 Domain Containing 4

Chromosome: CHR4: 52709275 -52783003

Locus: 4q12

Gene Diseases

The DCUN1D4 IKZF1 Fusion has been associated with the following diseases:

Disease Name
Sarcoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.