DCTN2-DENND3 Fusion FISH Probe
The DCTN2-DENND3 Fusion FISH Probe is used to confirm a fusion of the DCTN2 and DENND3 genes. The fusion of the DCTN2 and DENND3 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DCTN2-DENND3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DCTN2-DENND3-20-RERE | 20 (40 μL) | 200 μL |
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| DCTN2-DENND3-20-REOR | 20 (40 μL) | 200 μL |
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| DCTN2-DENND3-20-REGO | 20 (40 μL) | 200 μL |
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| DCTN2-DENND3-20-REGR | 20 (40 μL) | 200 μL |
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| DCTN2-DENND3-20-REAQ | 20 (40 μL) | 200 μL |
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| DCTN2-DENND3-20-ORRE | 20 (40 μL) | 200 μL |
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| DCTN2-DENND3-20-OROR | 20 (40 μL) | 200 μL |
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| DCTN2-DENND3-20-ORGO | 20 (40 μL) | 200 μL |
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| DCTN2-DENND3-20-ORAQ | 20 (40 μL) | 200 μL |
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| DCTN2-DENND3-20-GORE | 20 (40 μL) | 200 μL |
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| DCTN2-DENND3-20-GOOR | 20 (40 μL) | 200 μL |
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| DCTN2-DENND3-20-GOGO | 20 (40 μL) | 200 μL |
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| DCTN2-DENND3-20-GOGR | 20 (40 μL) | 200 μL |
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| DCTN2-DENND3-20-GOAQ | 20 (40 μL) | 200 μL |
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| DCTN2-DENND3-20-GRRE | 20 (40 μL) | 200 μL |
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| DCTN2-DENND3-20-GROR | 20 (40 μL) | 200 μL |
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| DCTN2-DENND3-20-GRGO | 20 (40 μL) | 200 μL |
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| DCTN2-DENND3-20-GRGR | 20 (40 μL) | 200 μL |
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| DCTN2-DENND3-20-GRAQ | 20 (40 μL) | 200 μL |
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| DCTN2-DENND3-20-AQRE | 20 (40 μL) | 200 μL |
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| DCTN2-DENND3-20-AQOR | 20 (40 μL) | 200 μL |
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| DCTN2-DENND3-20-AQGO | 20 (40 μL) | 200 μL |
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| DCTN2-DENND3-20-AQGR | 20 (40 μL) | 200 μL |
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| DCTN2-DENND3-20-AQAQ | 20 (40 μL) | 200 μL |
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DCTN2 Gene Summary
This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2012]
Gene Name: Dynactin Subunit 2
Chromosome: CHR12: 57924093 -57940978
Locus: 12q13.3
DENND3 Gene Summary
The DENN Domain Containing 3 (DENND3) gene is located on chr8 :142138719-142205900 at 8q24.3.
Gene Name: DENN Domain Containing 3
Chromosome: CHR8: 142138719 -142205900
Locus: 8q24.3
Gene Diseases
The DCTN2 DENND3 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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