DCTN2-DDX23 Fusion FISH Probe
The DCTN2-DDX23 Fusion FISH Probe is used to confirm a fusion of the DCTN2 and DDX23 genes. The fusion of the DCTN2 and DDX23 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DCTN2-DDX23-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DCTN2-DDX23-20-RERE | 20 (40 μL) | 200 μL |
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| DCTN2-DDX23-20-REOR | 20 (40 μL) | 200 μL |
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| DCTN2-DDX23-20-REGO | 20 (40 μL) | 200 μL |
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| DCTN2-DDX23-20-REGR | 20 (40 μL) | 200 μL |
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| DCTN2-DDX23-20-REAQ | 20 (40 μL) | 200 μL |
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| DCTN2-DDX23-20-ORRE | 20 (40 μL) | 200 μL |
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| DCTN2-DDX23-20-OROR | 20 (40 μL) | 200 μL |
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| DCTN2-DDX23-20-ORGO | 20 (40 μL) | 200 μL |
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| DCTN2-DDX23-20-ORAQ | 20 (40 μL) | 200 μL |
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| DCTN2-DDX23-20-GORE | 20 (40 μL) | 200 μL |
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| DCTN2-DDX23-20-GOOR | 20 (40 μL) | 200 μL |
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| DCTN2-DDX23-20-GOGO | 20 (40 μL) | 200 μL |
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| DCTN2-DDX23-20-GOGR | 20 (40 μL) | 200 μL |
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| DCTN2-DDX23-20-GOAQ | 20 (40 μL) | 200 μL |
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| DCTN2-DDX23-20-GRRE | 20 (40 μL) | 200 μL |
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| DCTN2-DDX23-20-GROR | 20 (40 μL) | 200 μL |
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| DCTN2-DDX23-20-GRGO | 20 (40 μL) | 200 μL |
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| DCTN2-DDX23-20-GRGR | 20 (40 μL) | 200 μL |
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| DCTN2-DDX23-20-GRAQ | 20 (40 μL) | 200 μL |
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| DCTN2-DDX23-20-AQRE | 20 (40 μL) | 200 μL |
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| DCTN2-DDX23-20-AQOR | 20 (40 μL) | 200 μL |
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| DCTN2-DDX23-20-AQGO | 20 (40 μL) | 200 μL |
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| DCTN2-DDX23-20-AQGR | 20 (40 μL) | 200 μL |
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| DCTN2-DDX23-20-AQAQ | 20 (40 μL) | 200 μL |
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DDX23 Gene Summary
This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the U5 snRNP complex; it may facilitate conformational changes in the spliceosome during nuclear pre-mRNA splicing. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: DEAD-box Helicase 23
Chromosome: CHR12: 49223538 -49245957
Locus: 12q13.12
DCTN2 Gene Summary
This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2012]
Gene Name: Dynactin Subunit 2
Chromosome: CHR12: 57924093 -57940978
Locus: 12q13.3
Gene Diseases
The DCTN2 DDX23 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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