DCPS-TIRAP Fusion FISH Probe
The DCPS-TIRAP Fusion FISH Probe is used to confirm a fusion of the DCPS and TIRAP genes. The fusion of the DCPS and TIRAP genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DCPS-TIRAP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DCPS-TIRAP-20-RERE | 20 (40 μL) | 200 μL |
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| DCPS-TIRAP-20-REOR | 20 (40 μL) | 200 μL |
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| DCPS-TIRAP-20-REGO | 20 (40 μL) | 200 μL |
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| DCPS-TIRAP-20-REGR | 20 (40 μL) | 200 μL |
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| DCPS-TIRAP-20-REAQ | 20 (40 μL) | 200 μL |
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| DCPS-TIRAP-20-ORRE | 20 (40 μL) | 200 μL |
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| DCPS-TIRAP-20-OROR | 20 (40 μL) | 200 μL |
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| DCPS-TIRAP-20-ORGO | 20 (40 μL) | 200 μL |
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| DCPS-TIRAP-20-ORAQ | 20 (40 μL) | 200 μL |
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| DCPS-TIRAP-20-GORE | 20 (40 μL) | 200 μL |
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| DCPS-TIRAP-20-GOOR | 20 (40 μL) | 200 μL |
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| DCPS-TIRAP-20-GOGO | 20 (40 μL) | 200 μL |
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| DCPS-TIRAP-20-GOGR | 20 (40 μL) | 200 μL |
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| DCPS-TIRAP-20-GOAQ | 20 (40 μL) | 200 μL |
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| DCPS-TIRAP-20-GRRE | 20 (40 μL) | 200 μL |
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| DCPS-TIRAP-20-GROR | 20 (40 μL) | 200 μL |
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| DCPS-TIRAP-20-GRGO | 20 (40 μL) | 200 μL |
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| DCPS-TIRAP-20-GRGR | 20 (40 μL) | 200 μL |
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| DCPS-TIRAP-20-GRAQ | 20 (40 μL) | 200 μL |
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| DCPS-TIRAP-20-AQRE | 20 (40 μL) | 200 μL |
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| DCPS-TIRAP-20-AQOR | 20 (40 μL) | 200 μL |
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| DCPS-TIRAP-20-AQGO | 20 (40 μL) | 200 μL |
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| DCPS-TIRAP-20-AQGR | 20 (40 μL) | 200 μL |
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| DCPS-TIRAP-20-AQAQ | 20 (40 μL) | 200 μL |
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DCPS Gene Summary
This gene encodes a member of the histidine triad family of pyrophosphatases that removes short mRNA fragments containing the 5′ mRNA cap structure, which appear in the 3′ → 5′ mRNA decay pathway, following deadenylation and exosome-mediated turnover. This enzyme hydrolyzes the triphosphate linkage of the cap structure (7-methylguanosine nucleoside triphosphate) to yield 7-methylguanosine monophosphate and nucleoside diphosphate. It protects the cell from the potentially toxic accumulation of these short, capped mRNA fragments, and regulates the activity of other cap-binding proteins, which are inhibited by their accumulation. It also acts as a transcript-specific modulator of pre-mRNA splicing and microRNA turnover. [provided by RefSeq, Apr 2017]
Gene Name: Decapping Enzyme, Scavenger
Chromosome: CHR11: 126173646 -126215644
Locus: 11q24.2
TIRAP Gene Summary
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
Gene Name: TIR Domain Containing Adaptor Protein
Chromosome: CHR11: 126152981 -126164828
Locus: 11q24.2
Gene Diseases
The DCPS TIRAP Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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