DCLK1-CLDN10 Fusion FISH Probe
The DCLK1-CLDN10 Fusion FISH Probe is used to confirm a fusion of the DCLK1 and CLDN10 genes. The fusion of the DCLK1 and CLDN10 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DCLK1-CLDN10-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DCLK1-CLDN10-20-RERE | 20 (40 μL) | 200 μL |
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| DCLK1-CLDN10-20-REOR | 20 (40 μL) | 200 μL |
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| DCLK1-CLDN10-20-REGO | 20 (40 μL) | 200 μL |
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| DCLK1-CLDN10-20-REGR | 20 (40 μL) | 200 μL |
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| DCLK1-CLDN10-20-REAQ | 20 (40 μL) | 200 μL |
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| DCLK1-CLDN10-20-ORRE | 20 (40 μL) | 200 μL |
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| DCLK1-CLDN10-20-OROR | 20 (40 μL) | 200 μL |
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| DCLK1-CLDN10-20-ORGO | 20 (40 μL) | 200 μL |
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| DCLK1-CLDN10-20-ORAQ | 20 (40 μL) | 200 μL |
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| DCLK1-CLDN10-20-GORE | 20 (40 μL) | 200 μL |
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| DCLK1-CLDN10-20-GOOR | 20 (40 μL) | 200 μL |
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| DCLK1-CLDN10-20-GOGO | 20 (40 μL) | 200 μL |
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| DCLK1-CLDN10-20-GOGR | 20 (40 μL) | 200 μL |
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| DCLK1-CLDN10-20-GOAQ | 20 (40 μL) | 200 μL |
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| DCLK1-CLDN10-20-GRRE | 20 (40 μL) | 200 μL |
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| DCLK1-CLDN10-20-GROR | 20 (40 μL) | 200 μL |
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| DCLK1-CLDN10-20-GRGO | 20 (40 μL) | 200 μL |
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| DCLK1-CLDN10-20-GRGR | 20 (40 μL) | 200 μL |
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| DCLK1-CLDN10-20-GRAQ | 20 (40 μL) | 200 μL |
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| DCLK1-CLDN10-20-AQRE | 20 (40 μL) | 200 μL |
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| DCLK1-CLDN10-20-AQOR | 20 (40 μL) | 200 μL |
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| DCLK1-CLDN10-20-AQGO | 20 (40 μL) | 200 μL |
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| DCLK1-CLDN10-20-AQGR | 20 (40 μL) | 200 μL |
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| DCLK1-CLDN10-20-AQAQ | 20 (40 μL) | 200 μL |
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CLDN10 Gene Summary
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The expression level of this gene is associated with recurrence of primary hepatocellular carcinoma. Six alternatively spliced transcript variants encoding different isoforms have been reported, but the transcript sequences of some variants are not determined.[provided by RefSeq, Jun 2010]
Gene Name: Claudin 10
Chromosome: CHR13: 96085852 -96232010
Locus: 13q32.1
DCLK1 Gene Summary
This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010]
Gene Name: Doublecortin Like Kinase 1
Chromosome: CHR13: 36342788 -36705514
Locus: 13q13.3
Gene Diseases
The DCLK1 CLDN10 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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