DBP-CA11 Fusion FISH Probe
The DBP-CA11 Fusion FISH Probe is used to confirm a fusion of the DBP and CA11 genes. The fusion of the DBP and CA11 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DBP-CA11-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DBP-CA11-20-RERE | 20 (40 μL) | 200 μL |
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| DBP-CA11-20-REOR | 20 (40 μL) | 200 μL |
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| DBP-CA11-20-REGO | 20 (40 μL) | 200 μL |
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| DBP-CA11-20-REGR | 20 (40 μL) | 200 μL |
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| DBP-CA11-20-REAQ | 20 (40 μL) | 200 μL |
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| DBP-CA11-20-ORRE | 20 (40 μL) | 200 μL |
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| DBP-CA11-20-OROR | 20 (40 μL) | 200 μL |
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| DBP-CA11-20-ORGO | 20 (40 μL) | 200 μL |
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| DBP-CA11-20-ORAQ | 20 (40 μL) | 200 μL |
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| DBP-CA11-20-GORE | 20 (40 μL) | 200 μL |
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| DBP-CA11-20-GOOR | 20 (40 μL) | 200 μL |
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| DBP-CA11-20-GOGO | 20 (40 μL) | 200 μL |
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| DBP-CA11-20-GOGR | 20 (40 μL) | 200 μL |
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| DBP-CA11-20-GOAQ | 20 (40 μL) | 200 μL |
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| DBP-CA11-20-GRRE | 20 (40 μL) | 200 μL |
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| DBP-CA11-20-GROR | 20 (40 μL) | 200 μL |
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| DBP-CA11-20-GRGO | 20 (40 μL) | 200 μL |
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| DBP-CA11-20-GRGR | 20 (40 μL) | 200 μL |
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| DBP-CA11-20-GRAQ | 20 (40 μL) | 200 μL |
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| DBP-CA11-20-AQRE | 20 (40 μL) | 200 μL |
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| DBP-CA11-20-AQOR | 20 (40 μL) | 200 μL |
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| DBP-CA11-20-AQGO | 20 (40 μL) | 200 μL |
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| DBP-CA11-20-AQGR | 20 (40 μL) | 200 μL |
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| DBP-CA11-20-AQAQ | 20 (40 μL) | 200 μL |
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CA11 Gene Summary
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system. [provided by RefSeq, Jul 2008]
Gene Name: Carbonic Anhydrase 11
Chromosome: CHR19: 49141271 -49149451
Locus: 19q13.33
DBP Gene Summary
The protein encoded by this gene is a member of the PAR bZIP transcription factor family and binds to specific sequences in the promoters of several genes, such as albumin, CYP2A4, and CYP2A5. The encoded protein can bind DNA as a homo- or heterodimer and is involved in the regulation of some circadian rhythm genes. [provided by RefSeq, Jul 2014]
Gene Name: D-box Binding PAR BZIP Transcription Factor
Chromosome: CHR19: 49133816 -49140639
Locus: 19q13.33
Gene Diseases
The DBP CA11 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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