DAPP1-COL4A3 Fusion FISH Probe
The DAPP1-COL4A3 Fusion FISH Probe is used to confirm a fusion of the DAPP1 and COL4A3 genes. The fusion of the DAPP1 and COL4A3 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DAPP1-COL4A3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DAPP1-COL4A3-20-RERE | 20 (40 μL) | 200 μL |
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| DAPP1-COL4A3-20-REOR | 20 (40 μL) | 200 μL |
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| DAPP1-COL4A3-20-REGO | 20 (40 μL) | 200 μL |
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| DAPP1-COL4A3-20-REGR | 20 (40 μL) | 200 μL |
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| DAPP1-COL4A3-20-REAQ | 20 (40 μL) | 200 μL |
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| DAPP1-COL4A3-20-ORRE | 20 (40 μL) | 200 μL |
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| DAPP1-COL4A3-20-OROR | 20 (40 μL) | 200 μL |
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| DAPP1-COL4A3-20-ORGO | 20 (40 μL) | 200 μL |
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| DAPP1-COL4A3-20-ORAQ | 20 (40 μL) | 200 μL |
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| DAPP1-COL4A3-20-GORE | 20 (40 μL) | 200 μL |
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| DAPP1-COL4A3-20-GOOR | 20 (40 μL) | 200 μL |
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| DAPP1-COL4A3-20-GOGO | 20 (40 μL) | 200 μL |
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| DAPP1-COL4A3-20-GOGR | 20 (40 μL) | 200 μL |
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| DAPP1-COL4A3-20-GOAQ | 20 (40 μL) | 200 μL |
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| DAPP1-COL4A3-20-GRRE | 20 (40 μL) | 200 μL |
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| DAPP1-COL4A3-20-GROR | 20 (40 μL) | 200 μL |
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| DAPP1-COL4A3-20-GRGO | 20 (40 μL) | 200 μL |
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| DAPP1-COL4A3-20-GRGR | 20 (40 μL) | 200 μL |
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| DAPP1-COL4A3-20-GRAQ | 20 (40 μL) | 200 μL |
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| DAPP1-COL4A3-20-AQRE | 20 (40 μL) | 200 μL |
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| DAPP1-COL4A3-20-AQOR | 20 (40 μL) | 200 μL |
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| DAPP1-COL4A3-20-AQGO | 20 (40 μL) | 200 μL |
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| DAPP1-COL4A3-20-AQGR | 20 (40 μL) | 200 μL |
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| DAPP1-COL4A3-20-AQAQ | 20 (40 μL) | 200 μL |
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COL4A3 Gene Summary
Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jun 2010]
Gene Name: Collagen Type IV Alpha 3 Chain
Chromosome: CHR2: 228029280 -228179508
Locus: 2q36.3
DAPP1 Gene Summary
The Dual Adaptor Of Phosphotyrosine And 3-phosphoinositides 1 (DAPP1) gene is located on chr4 :100737980-100791346 at 4q23.
Gene Name: Dual Adaptor Of Phosphotyrosine And 3-phosphoinositides 1
Chromosome: CHR4: 100737980 -100791346
Locus: 4q23
Gene Diseases
The DAPP1 COL4A3 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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