DAP3-TIPRL Fusion FISH Probe
The DAP3-TIPRL Fusion FISH Probe is used to confirm a fusion of the DAP3 and TIPRL genes. The fusion of the DAP3 and TIPRL genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DAP3-TIPRL-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DAP3-TIPRL-20-RERE | 20 (40 μL) | 200 μL |
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| DAP3-TIPRL-20-REOR | 20 (40 μL) | 200 μL |
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| DAP3-TIPRL-20-REGO | 20 (40 μL) | 200 μL |
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| DAP3-TIPRL-20-REGR | 20 (40 μL) | 200 μL |
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| DAP3-TIPRL-20-REAQ | 20 (40 μL) | 200 μL |
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| DAP3-TIPRL-20-ORRE | 20 (40 μL) | 200 μL |
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| DAP3-TIPRL-20-OROR | 20 (40 μL) | 200 μL |
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| DAP3-TIPRL-20-ORGO | 20 (40 μL) | 200 μL |
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| DAP3-TIPRL-20-ORAQ | 20 (40 μL) | 200 μL |
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| DAP3-TIPRL-20-GORE | 20 (40 μL) | 200 μL |
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| DAP3-TIPRL-20-GOOR | 20 (40 μL) | 200 μL |
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| DAP3-TIPRL-20-GOGO | 20 (40 μL) | 200 μL |
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| DAP3-TIPRL-20-GOGR | 20 (40 μL) | 200 μL |
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| DAP3-TIPRL-20-GOAQ | 20 (40 μL) | 200 μL |
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| DAP3-TIPRL-20-GRRE | 20 (40 μL) | 200 μL |
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| DAP3-TIPRL-20-GROR | 20 (40 μL) | 200 μL |
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| DAP3-TIPRL-20-GRGO | 20 (40 μL) | 200 μL |
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| DAP3-TIPRL-20-GRGR | 20 (40 μL) | 200 μL |
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| DAP3-TIPRL-20-GRAQ | 20 (40 μL) | 200 μL |
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| DAP3-TIPRL-20-AQRE | 20 (40 μL) | 200 μL |
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| DAP3-TIPRL-20-AQOR | 20 (40 μL) | 200 μL |
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| DAP3-TIPRL-20-AQGO | 20 (40 μL) | 200 μL |
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| DAP3-TIPRL-20-AQGR | 20 (40 μL) | 200 μL |
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| DAP3-TIPRL-20-AQAQ | 20 (40 μL) | 200 μL |
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DAP3 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that also participates in apoptotic pathways which are initiated by tumor necrosis factor-alpha, Fas ligand, and gamma interferon. This protein potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq, Dec 2010]
Gene Name: Death Associated Protein 3
Chromosome: CHR1: 155658881 -155708800
Locus: 1q22
TIPRL Gene Summary
TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed 17384681]).[supplied by OMIM, Nov 2010]
Gene Name: TOR Signaling Pathway Regulator
Chromosome: CHR1: 168148170 -168171351
Locus: 1q24.2
Gene Diseases
The DAP3 TIPRL Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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