DACH1-TNFSF11 Fusion FISH Probe
The DACH1-TNFSF11 Fusion FISH Probe is used to confirm a fusion of the DACH1 and TNFSF11 genes. The fusion of the DACH1 and TNFSF11 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DACH1-TNFSF11-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DACH1-TNFSF11-20-RERE | 20 (40 μL) | 200 μL |
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| DACH1-TNFSF11-20-REOR | 20 (40 μL) | 200 μL |
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| DACH1-TNFSF11-20-REGO | 20 (40 μL) | 200 μL |
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| DACH1-TNFSF11-20-REGR | 20 (40 μL) | 200 μL |
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| DACH1-TNFSF11-20-REAQ | 20 (40 μL) | 200 μL |
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| DACH1-TNFSF11-20-ORRE | 20 (40 μL) | 200 μL |
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| DACH1-TNFSF11-20-OROR | 20 (40 μL) | 200 μL |
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| DACH1-TNFSF11-20-ORGO | 20 (40 μL) | 200 μL |
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| DACH1-TNFSF11-20-ORAQ | 20 (40 μL) | 200 μL |
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| DACH1-TNFSF11-20-GORE | 20 (40 μL) | 200 μL |
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| DACH1-TNFSF11-20-GOOR | 20 (40 μL) | 200 μL |
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| DACH1-TNFSF11-20-GOGO | 20 (40 μL) | 200 μL |
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| DACH1-TNFSF11-20-GOGR | 20 (40 μL) | 200 μL |
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| DACH1-TNFSF11-20-GOAQ | 20 (40 μL) | 200 μL |
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| DACH1-TNFSF11-20-GRRE | 20 (40 μL) | 200 μL |
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| DACH1-TNFSF11-20-GROR | 20 (40 μL) | 200 μL |
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| DACH1-TNFSF11-20-GRGO | 20 (40 μL) | 200 μL |
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| DACH1-TNFSF11-20-GRGR | 20 (40 μL) | 200 μL |
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| DACH1-TNFSF11-20-GRAQ | 20 (40 μL) | 200 μL |
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| DACH1-TNFSF11-20-AQRE | 20 (40 μL) | 200 μL |
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| DACH1-TNFSF11-20-AQOR | 20 (40 μL) | 200 μL |
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| DACH1-TNFSF11-20-AQGO | 20 (40 μL) | 200 μL |
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| DACH1-TNFSF11-20-AQGR | 20 (40 μL) | 200 μL |
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| DACH1-TNFSF11-20-AQAQ | 20 (40 μL) | 200 μL |
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DACH1 Gene Summary
This gene encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic cancer, and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Name: Dachshund Family Transcription Factor 1
Chromosome: CHR13: 72012097 -72441330
Locus: 13q21.33
TNFSF11 Gene Summary
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]
Gene Name: TNF Superfamily Member 11
Chromosome: CHR13: 43136871 -43182149
Locus: 13q14.11
Gene Diseases
The DACH1 TNFSF11 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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