DAB2-FASTKD3 Fusion FISH Probe
The DAB2-FASTKD3 Fusion FISH Probe is used to confirm a fusion of the DAB2 and FASTKD3 genes. The fusion of the DAB2 and FASTKD3 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DAB2-FASTKD3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DAB2-FASTKD3-20-RERE | 20 (40 μL) | 200 μL |
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| DAB2-FASTKD3-20-REOR | 20 (40 μL) | 200 μL |
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| DAB2-FASTKD3-20-REGO | 20 (40 μL) | 200 μL |
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| DAB2-FASTKD3-20-REGR | 20 (40 μL) | 200 μL |
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| DAB2-FASTKD3-20-REAQ | 20 (40 μL) | 200 μL |
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| DAB2-FASTKD3-20-ORRE | 20 (40 μL) | 200 μL |
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| DAB2-FASTKD3-20-OROR | 20 (40 μL) | 200 μL |
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| DAB2-FASTKD3-20-ORGO | 20 (40 μL) | 200 μL |
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| DAB2-FASTKD3-20-ORAQ | 20 (40 μL) | 200 μL |
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| DAB2-FASTKD3-20-GORE | 20 (40 μL) | 200 μL |
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| DAB2-FASTKD3-20-GOOR | 20 (40 μL) | 200 μL |
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| DAB2-FASTKD3-20-GOGO | 20 (40 μL) | 200 μL |
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| DAB2-FASTKD3-20-GOGR | 20 (40 μL) | 200 μL |
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| DAB2-FASTKD3-20-GOAQ | 20 (40 μL) | 200 μL |
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| DAB2-FASTKD3-20-GRRE | 20 (40 μL) | 200 μL |
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| DAB2-FASTKD3-20-GROR | 20 (40 μL) | 200 μL |
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| DAB2-FASTKD3-20-GRGO | 20 (40 μL) | 200 μL |
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| DAB2-FASTKD3-20-GRGR | 20 (40 μL) | 200 μL |
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| DAB2-FASTKD3-20-GRAQ | 20 (40 μL) | 200 μL |
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| DAB2-FASTKD3-20-AQRE | 20 (40 μL) | 200 μL |
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| DAB2-FASTKD3-20-AQOR | 20 (40 μL) | 200 μL |
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| DAB2-FASTKD3-20-AQGO | 20 (40 μL) | 200 μL |
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| DAB2-FASTKD3-20-AQGR | 20 (40 μL) | 200 μL |
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| DAB2-FASTKD3-20-AQAQ | 20 (40 μL) | 200 μL |
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DAB2 Gene Summary
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: DAB2, Clathrin Adaptor Protein
Chromosome: CHR5: 39371779 -39425335
Locus: 5p13.1
FASTKD3 Gene Summary
This gene encodes a member of a small family of Fas-activated serine/threonine kinase domain (FASTKD) containing proteins that share an amino terminal mitochondrial targeting domain and multiple carboxy terminal FAST domains as well as a putative RNA-binding RAP domain. The members of this family are ubiquitously expressed and are generally most abundant in mitochondria-enriched tissues such as heart, skeletal muscle and brown-adipose tissue. Some members of this protein family may play a role in apoptosis. The protein encoded by this gene interacts with components of the mitochondrial respiratory and translation networks. A pseudogene of this gene is also present on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Gene Name: FAST Kinase Domains 3
Chromosome: CHR5: 7859271 -7869150
Locus: 5p15.31
Gene Diseases
The DAB2 FASTKD3 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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