DAB2-ARSB Fusion FISH Probe
The DAB2-ARSB Fusion FISH Probe is used to confirm a fusion of the DAB2 and ARSB genes. The fusion of the DAB2 and ARSB genes has been associated with Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DAB2-ARSB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| DAB2-ARSB-20-RERE | 20 (40 μL) | 200 μL |
|
|
| DAB2-ARSB-20-REOR | 20 (40 μL) | 200 μL |
|
|
| DAB2-ARSB-20-REGO | 20 (40 μL) | 200 μL |
|
|
| DAB2-ARSB-20-REGR | 20 (40 μL) | 200 μL |
|
|
| DAB2-ARSB-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| DAB2-ARSB-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| DAB2-ARSB-20-OROR | 20 (40 μL) | 200 μL |
|
|
| DAB2-ARSB-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| DAB2-ARSB-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| DAB2-ARSB-20-GORE | 20 (40 μL) | 200 μL |
|
|
| DAB2-ARSB-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| DAB2-ARSB-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| DAB2-ARSB-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| DAB2-ARSB-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| DAB2-ARSB-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| DAB2-ARSB-20-GROR | 20 (40 μL) | 200 μL |
|
|
| DAB2-ARSB-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| DAB2-ARSB-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| DAB2-ARSB-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| DAB2-ARSB-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| DAB2-ARSB-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| DAB2-ARSB-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| DAB2-ARSB-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| DAB2-ARSB-20-AQAQ | 20 (40 μL) | 200 μL |
|
ARSB Gene Summary
Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targeted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2016]
Gene Name: Arylsulfatase B
Chromosome: CHR5: 78073036 -78282357
Locus: 5q14.1
DAB2 Gene Summary
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: DAB2, Clathrin Adaptor Protein
Chromosome: CHR5: 39371779 -39425335
Locus: 5p13.1
Gene Diseases
The DAB2 ARSB Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Adrenocortical Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|