DAAM1-MNAT1 Fusion FISH Probe
The DAAM1-MNAT1 Fusion FISH Probe is used to confirm a fusion of the DAAM1 and MNAT1 genes. The fusion of the DAAM1 and MNAT1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DAAM1-MNAT1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DAAM1-MNAT1-20-RERE | 20 (40 μL) | 200 μL |
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| DAAM1-MNAT1-20-REOR | 20 (40 μL) | 200 μL |
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| DAAM1-MNAT1-20-REGO | 20 (40 μL) | 200 μL |
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| DAAM1-MNAT1-20-REGR | 20 (40 μL) | 200 μL |
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| DAAM1-MNAT1-20-REAQ | 20 (40 μL) | 200 μL |
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| DAAM1-MNAT1-20-ORRE | 20 (40 μL) | 200 μL |
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| DAAM1-MNAT1-20-OROR | 20 (40 μL) | 200 μL |
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| DAAM1-MNAT1-20-ORGO | 20 (40 μL) | 200 μL |
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| DAAM1-MNAT1-20-ORAQ | 20 (40 μL) | 200 μL |
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| DAAM1-MNAT1-20-GORE | 20 (40 μL) | 200 μL |
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| DAAM1-MNAT1-20-GOOR | 20 (40 μL) | 200 μL |
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| DAAM1-MNAT1-20-GOGO | 20 (40 μL) | 200 μL |
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| DAAM1-MNAT1-20-GOGR | 20 (40 μL) | 200 μL |
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| DAAM1-MNAT1-20-GOAQ | 20 (40 μL) | 200 μL |
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| DAAM1-MNAT1-20-GRRE | 20 (40 μL) | 200 μL |
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| DAAM1-MNAT1-20-GROR | 20 (40 μL) | 200 μL |
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| DAAM1-MNAT1-20-GRGO | 20 (40 μL) | 200 μL |
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| DAAM1-MNAT1-20-GRGR | 20 (40 μL) | 200 μL |
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| DAAM1-MNAT1-20-GRAQ | 20 (40 μL) | 200 μL |
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| DAAM1-MNAT1-20-AQRE | 20 (40 μL) | 200 μL |
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| DAAM1-MNAT1-20-AQOR | 20 (40 μL) | 200 μL |
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| DAAM1-MNAT1-20-AQGO | 20 (40 μL) | 200 μL |
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| DAAM1-MNAT1-20-AQGR | 20 (40 μL) | 200 μL |
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| DAAM1-MNAT1-20-AQAQ | 20 (40 μL) | 200 μL |
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MNAT1 Gene Summary
The protein encoded by this gene, along with cyclin H and CDK7, forms the CDK-activating kinase (CAK) enzymatic complex. This complex activates several cyclin-associated kinases and can also associate with TFIIH to activate transcription by RNA polymerase II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Name: MNAT1, CDK Activating Kinase Assembly Factor
Chromosome: CHR14: 61201458 -61435398
Locus: 14q23.1
DAAM1 Gene Summary
Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2012]
Gene Name: Dishevelled Associated Activator Of Morphogenesis 1
Chromosome: CHR14: 59655398 -59836471
Locus: 14q23.1
Gene Diseases
The DAAM1 MNAT1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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