D2HGDH-CUL3 Fusion FISH Probe
The D2HGDH-CUL3 Fusion FISH Probe is used to confirm a fusion of the D2HGDH and CUL3 genes. The fusion of the D2HGDH and CUL3 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| D2HGDH-CUL3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| D2HGDH-CUL3-20-RERE | 20 (40 μL) | 200 μL |
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| D2HGDH-CUL3-20-REOR | 20 (40 μL) | 200 μL |
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| D2HGDH-CUL3-20-REGO | 20 (40 μL) | 200 μL |
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| D2HGDH-CUL3-20-REGR | 20 (40 μL) | 200 μL |
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| D2HGDH-CUL3-20-REAQ | 20 (40 μL) | 200 μL |
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| D2HGDH-CUL3-20-ORRE | 20 (40 μL) | 200 μL |
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| D2HGDH-CUL3-20-OROR | 20 (40 μL) | 200 μL |
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| D2HGDH-CUL3-20-ORGO | 20 (40 μL) | 200 μL |
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| D2HGDH-CUL3-20-ORAQ | 20 (40 μL) | 200 μL |
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| D2HGDH-CUL3-20-GORE | 20 (40 μL) | 200 μL |
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| D2HGDH-CUL3-20-GOOR | 20 (40 μL) | 200 μL |
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| D2HGDH-CUL3-20-GOGO | 20 (40 μL) | 200 μL |
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| D2HGDH-CUL3-20-GOGR | 20 (40 μL) | 200 μL |
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| D2HGDH-CUL3-20-GOAQ | 20 (40 μL) | 200 μL |
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| D2HGDH-CUL3-20-GRRE | 20 (40 μL) | 200 μL |
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| D2HGDH-CUL3-20-GROR | 20 (40 μL) | 200 μL |
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| D2HGDH-CUL3-20-GRGO | 20 (40 μL) | 200 μL |
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| D2HGDH-CUL3-20-GRGR | 20 (40 μL) | 200 μL |
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| D2HGDH-CUL3-20-GRAQ | 20 (40 μL) | 200 μL |
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| D2HGDH-CUL3-20-AQRE | 20 (40 μL) | 200 μL |
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| D2HGDH-CUL3-20-AQOR | 20 (40 μL) | 200 μL |
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| D2HGDH-CUL3-20-AQGO | 20 (40 μL) | 200 μL |
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| D2HGDH-CUL3-20-AQGR | 20 (40 μL) | 200 μL |
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| D2HGDH-CUL3-20-AQAQ | 20 (40 μL) | 200 μL |
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CUL3 Gene Summary
This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation. Mutations in this gene are a cause of type 2E pseudohypoaldosteronism. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Gene Name: Cullin 3
Chromosome: CHR2: 225334868 -225450110
Locus: 2q36.2
D2HGDH Gene Summary
This gene encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active in heart and brain, converts D-2-hydroxyglutarate to 2-ketoglutarate. Mutations in this gene are present in D-2-hydroxyglutaric aciduria, a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features. [provided by RefSeq, Jul 2008]
Gene Name: D-2-hydroxyglutarate Dehydrogenase
Chromosome: CHR2: 242674029 -242708231
Locus: 2q37.3
Gene Diseases
The D2HGDH CUL3 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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