CYTH1-MRC2 Fusion FISH Probe
The CYTH1-MRC2 Fusion FISH Probe is used to confirm a fusion of the CYTH1 and MRC2 genes. The fusion of the CYTH1 and MRC2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CYTH1-MRC2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CYTH1-MRC2-20-RERE | 20 (40 μL) | 200 μL |
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| CYTH1-MRC2-20-REOR | 20 (40 μL) | 200 μL |
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| CYTH1-MRC2-20-REGO | 20 (40 μL) | 200 μL |
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| CYTH1-MRC2-20-REGR | 20 (40 μL) | 200 μL |
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| CYTH1-MRC2-20-REAQ | 20 (40 μL) | 200 μL |
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| CYTH1-MRC2-20-ORRE | 20 (40 μL) | 200 μL |
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| CYTH1-MRC2-20-OROR | 20 (40 μL) | 200 μL |
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| CYTH1-MRC2-20-ORGO | 20 (40 μL) | 200 μL |
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| CYTH1-MRC2-20-ORAQ | 20 (40 μL) | 200 μL |
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| CYTH1-MRC2-20-GORE | 20 (40 μL) | 200 μL |
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| CYTH1-MRC2-20-GOOR | 20 (40 μL) | 200 μL |
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| CYTH1-MRC2-20-GOGO | 20 (40 μL) | 200 μL |
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| CYTH1-MRC2-20-GOGR | 20 (40 μL) | 200 μL |
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| CYTH1-MRC2-20-GOAQ | 20 (40 μL) | 200 μL |
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| CYTH1-MRC2-20-GRRE | 20 (40 μL) | 200 μL |
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| CYTH1-MRC2-20-GROR | 20 (40 μL) | 200 μL |
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| CYTH1-MRC2-20-GRGO | 20 (40 μL) | 200 μL |
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| CYTH1-MRC2-20-GRGR | 20 (40 μL) | 200 μL |
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| CYTH1-MRC2-20-GRAQ | 20 (40 μL) | 200 μL |
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| CYTH1-MRC2-20-AQRE | 20 (40 μL) | 200 μL |
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| CYTH1-MRC2-20-AQOR | 20 (40 μL) | 200 μL |
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| CYTH1-MRC2-20-AQGO | 20 (40 μL) | 200 μL |
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| CYTH1-MRC2-20-AQGR | 20 (40 μL) | 200 μL |
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| CYTH1-MRC2-20-AQAQ | 20 (40 μL) | 200 μL |
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CYTH1 Gene Summary
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Name: Cytohesin 1
Chromosome: CHR17: 76670129 -76778376
Locus: 17q25.3
MRC2 Gene Summary
This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012]
Gene Name: Mannose Receptor C Type 2
Chromosome: CHR17: 60704761 -60770952
Locus: 17q23.2
Gene Diseases
The CYTH1 MRC2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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