CYTH1-MACROD1 Fusion FISH Probe
The CYTH1-MACROD1 Fusion FISH Probe is used to confirm a fusion of the CYTH1 and MACROD1 genes. The fusion of the CYTH1 and MACROD1 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CYTH1-MACROD1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CYTH1-MACROD1-20-RERE | 20 (40 μL) | 200 μL |
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| CYTH1-MACROD1-20-REOR | 20 (40 μL) | 200 μL |
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| CYTH1-MACROD1-20-REGO | 20 (40 μL) | 200 μL |
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| CYTH1-MACROD1-20-REGR | 20 (40 μL) | 200 μL |
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| CYTH1-MACROD1-20-REAQ | 20 (40 μL) | 200 μL |
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| CYTH1-MACROD1-20-ORRE | 20 (40 μL) | 200 μL |
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| CYTH1-MACROD1-20-OROR | 20 (40 μL) | 200 μL |
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| CYTH1-MACROD1-20-ORGO | 20 (40 μL) | 200 μL |
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| CYTH1-MACROD1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CYTH1-MACROD1-20-GORE | 20 (40 μL) | 200 μL |
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| CYTH1-MACROD1-20-GOOR | 20 (40 μL) | 200 μL |
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| CYTH1-MACROD1-20-GOGO | 20 (40 μL) | 200 μL |
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| CYTH1-MACROD1-20-GOGR | 20 (40 μL) | 200 μL |
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| CYTH1-MACROD1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CYTH1-MACROD1-20-GRRE | 20 (40 μL) | 200 μL |
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| CYTH1-MACROD1-20-GROR | 20 (40 μL) | 200 μL |
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| CYTH1-MACROD1-20-GRGO | 20 (40 μL) | 200 μL |
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| CYTH1-MACROD1-20-GRGR | 20 (40 μL) | 200 μL |
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| CYTH1-MACROD1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CYTH1-MACROD1-20-AQRE | 20 (40 μL) | 200 μL |
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| CYTH1-MACROD1-20-AQOR | 20 (40 μL) | 200 μL |
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| CYTH1-MACROD1-20-AQGO | 20 (40 μL) | 200 μL |
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| CYTH1-MACROD1-20-AQGR | 20 (40 μL) | 200 μL |
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| CYTH1-MACROD1-20-AQAQ | 20 (40 μL) | 200 μL |
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CYTH1 Gene Summary
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Name: Cytohesin 1
Chromosome: CHR17: 76670129 -76778376
Locus: 17q25.3
MACROD1 Gene Summary
The MACRO Domain Containing 1 (MACROD1) gene is located on chr11 :63766029-63933585 at 11q13.1.
Gene Name: MACRO Domain Containing 1
Chromosome: CHR11: 63766029 -63933585
Locus: 11q13.1
Gene Diseases
The CYTH1 MACROD1 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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