CYTH1-KCNJ4 Fusion FISH Probe
The CYTH1-KCNJ4 Fusion FISH Probe is used to confirm a fusion of the CYTH1 and KCNJ4 genes. The fusion of the CYTH1 and KCNJ4 genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CYTH1-KCNJ4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CYTH1-KCNJ4-20-RERE | 20 (40 μL) | 200 μL |
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| CYTH1-KCNJ4-20-REOR | 20 (40 μL) | 200 μL |
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| CYTH1-KCNJ4-20-REGO | 20 (40 μL) | 200 μL |
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| CYTH1-KCNJ4-20-REGR | 20 (40 μL) | 200 μL |
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| CYTH1-KCNJ4-20-REAQ | 20 (40 μL) | 200 μL |
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| CYTH1-KCNJ4-20-ORRE | 20 (40 μL) | 200 μL |
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| CYTH1-KCNJ4-20-OROR | 20 (40 μL) | 200 μL |
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| CYTH1-KCNJ4-20-ORGO | 20 (40 μL) | 200 μL |
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| CYTH1-KCNJ4-20-ORAQ | 20 (40 μL) | 200 μL |
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| CYTH1-KCNJ4-20-GORE | 20 (40 μL) | 200 μL |
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| CYTH1-KCNJ4-20-GOOR | 20 (40 μL) | 200 μL |
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| CYTH1-KCNJ4-20-GOGO | 20 (40 μL) | 200 μL |
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| CYTH1-KCNJ4-20-GOGR | 20 (40 μL) | 200 μL |
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| CYTH1-KCNJ4-20-GOAQ | 20 (40 μL) | 200 μL |
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| CYTH1-KCNJ4-20-GRRE | 20 (40 μL) | 200 μL |
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| CYTH1-KCNJ4-20-GROR | 20 (40 μL) | 200 μL |
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| CYTH1-KCNJ4-20-GRGO | 20 (40 μL) | 200 μL |
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| CYTH1-KCNJ4-20-GRGR | 20 (40 μL) | 200 μL |
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| CYTH1-KCNJ4-20-GRAQ | 20 (40 μL) | 200 μL |
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| CYTH1-KCNJ4-20-AQRE | 20 (40 μL) | 200 μL |
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| CYTH1-KCNJ4-20-AQOR | 20 (40 μL) | 200 μL |
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| CYTH1-KCNJ4-20-AQGO | 20 (40 μL) | 200 μL |
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| CYTH1-KCNJ4-20-AQGR | 20 (40 μL) | 200 μL |
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| CYTH1-KCNJ4-20-AQAQ | 20 (40 μL) | 200 μL |
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KCNJ4 Gene Summary
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Potassium Voltage-gated Channel Subfamily J Member 4
Chromosome: CHR22: 38822332 -38851203
Locus: 22q13.1
CYTH1 Gene Summary
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Name: Cytohesin 1
Chromosome: CHR17: 76670129 -76778376
Locus: 17q25.3
Gene Diseases
The CYTH1 KCNJ4 Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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