CYP7B1-EPS15 Fusion FISH Probe
The CYP7B1-EPS15 Fusion FISH Probe is used to confirm a fusion of the CYP7B1 and EPS15 genes. The fusion of the CYP7B1 and EPS15 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CYP7B1-EPS15-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CYP7B1-EPS15-20-RERE | 20 (40 μL) | 200 μL |
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| CYP7B1-EPS15-20-REOR | 20 (40 μL) | 200 μL |
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| CYP7B1-EPS15-20-REGO | 20 (40 μL) | 200 μL |
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| CYP7B1-EPS15-20-REGR | 20 (40 μL) | 200 μL |
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| CYP7B1-EPS15-20-REAQ | 20 (40 μL) | 200 μL |
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| CYP7B1-EPS15-20-ORRE | 20 (40 μL) | 200 μL |
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| CYP7B1-EPS15-20-OROR | 20 (40 μL) | 200 μL |
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| CYP7B1-EPS15-20-ORGO | 20 (40 μL) | 200 μL |
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| CYP7B1-EPS15-20-ORAQ | 20 (40 μL) | 200 μL |
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| CYP7B1-EPS15-20-GORE | 20 (40 μL) | 200 μL |
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| CYP7B1-EPS15-20-GOOR | 20 (40 μL) | 200 μL |
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| CYP7B1-EPS15-20-GOGO | 20 (40 μL) | 200 μL |
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| CYP7B1-EPS15-20-GOGR | 20 (40 μL) | 200 μL |
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| CYP7B1-EPS15-20-GOAQ | 20 (40 μL) | 200 μL |
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| CYP7B1-EPS15-20-GRRE | 20 (40 μL) | 200 μL |
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| CYP7B1-EPS15-20-GROR | 20 (40 μL) | 200 μL |
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| CYP7B1-EPS15-20-GRGO | 20 (40 μL) | 200 μL |
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| CYP7B1-EPS15-20-GRGR | 20 (40 μL) | 200 μL |
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| CYP7B1-EPS15-20-GRAQ | 20 (40 μL) | 200 μL |
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| CYP7B1-EPS15-20-AQRE | 20 (40 μL) | 200 μL |
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| CYP7B1-EPS15-20-AQOR | 20 (40 μL) | 200 μL |
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| CYP7B1-EPS15-20-AQGO | 20 (40 μL) | 200 μL |
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| CYP7B1-EPS15-20-AQGR | 20 (40 μL) | 200 μL |
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| CYP7B1-EPS15-20-AQAQ | 20 (40 μL) | 200 μL |
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EPS15 Gene Summary
This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2009]
Gene Name: Epidermal Growth Factor Receptor Pathway Substrate 15
Chromosome: CHR1: 51819934 -51984995
Locus: 1p32.3
CYP7B1 Gene Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids. This enzyme likely plays a minor role in total bile acid synthesis, but may also be involved in the development of atherosclerosis, neurosteroid metabolism and sex hormone synthesis. Mutations in this gene have been associated with hereditary spastic paraplegia (SPG5 or HSP), an autosomal recessive disorder. [provided by RefSeq, Apr 2016]
Gene Name: Cytochrome P450 Family 7 Subfamily B Member 1
Chromosome: CHR8: 65508528 -65711348
Locus: 8q12.3
Gene Diseases
The CYP7B1 EPS15 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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